Volume : 8, Issue : 3, March - 2019

Association between red cell distribution width increase with severity of disease and mortality in pediatric patient with sepsis

G N Yanni, M Lubis, C Yoel, T Devina

Abstract :

An increase in red cell distribution width (RDW) from baseline is signi􀃶cantly associated with adverse clinical outcomes in adult with sepsis. However, the role of RDW changes as severity and mortality predictors in pediatric population remains unclear. Therefore, we investigated the prognostic signi􀃶cance of changes in RDW in pediatric patient with sepsis. This study conducted to evaluate the association between increased RDW level with severity of disease and mortality in pediatric patients with sepsis. We prospectively enrolled 89 patients who were admitted to Pediatric Intensive Care Unit (PICU) with sepsis from December 2013 to June 2014. Red cell distribution width was measured at admission and at 72 hours. Severity of disease was assessed with PELOD score, mechanical ventilator use, and length of stay in PICU. Pediatric Logistic Organ Dysfunction (PELOD) score was measured at 72 hours of admission. We also recorded hemoglobin level, nutritional status, diagnosis on admission, as well as mortality. There were 52 (58.4%) patients with increase in RDW level at 72 hours. There were no signi􀃶cant difference on PELOD score (P = 0.327), length of stay in PICU (P = 0.713) and mechanical ventilator use (P = 0.444) between the increased RDW and no increased RDW group. Mortality in increased and no increased RDW group was 32.2% (29 patients) and 17.9% (16 patients), respectively but the difference was not signi􀃶cant statistically (P = 0.224). There was no signi􀃶cant association between RDW increase with severity of disease and mortality in pediatric patient with sepsis.