Volume : 8, Issue : 3, March - 2019

Therapeutic potential of Cell transplantation in a case of adult triplegic cerebral palsy

Dr. Alok Sharma, Ms. Pooja Kulkarni, Dr. Hemangi Sane, Dr. Nandini Gokulchandran, Dr. Khushboo Bhagwanani, Dr. Prerna Badhe, Mr. Samson Nivins

Abstract :

The safety and efficacy of cellular transplantation has been established in pediatric cereal palsy (CP). However, not many studies have been performed to determine its efficacy in adult CP. Adults with CP are at a higher risk of secondary complications. They have an overall lower fitness level, reduced muscle mass, neuromuscular inefficiency, and limited physical activities. Effects of long-term rehabilitation also eventually plateau in these individuals. To study the effect of cellular transplantation in adult CP, we administered a 27-year-old female, diagnosed as spastic triplegic cereal palsy, with autologous bone marrow mononuclear cells intrathecally followed by neurorehabilitation. The patient was followed up after 4 and 6 months of transplantation. She was then administered a second transplantation and later followed up after 5 months. Improvements were noted in voluntary control, spasticity, balance and gait. PET CT scan ain was performed before and 6 months after intervention to monitor the outcome of intervention at a cellular level. On the comparative PET CT scan, metabolic improvements were recorded in bilateral paracentral lobule, thalamus, medial temporal and cerebellum regions. No major adverse effects were noted after both the interventions. The results suggest that BMMNC transplantation is potentially safe and effective therapy for adults with CP. Hence, cellular transplantation in adult CP may help address the complications and improve their quality of life.