Volume : 8, Issue : 3, March - 2019

ROLE OF CLONIDINE AND ATENOLOL IN ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dr. Neha Choudhary, Dr. Sanjeev Kumar

Abstract :

Introduction Laryngoscopy and endotracheal intubation are potent stimuli that can induce increased sympathetic activity leading to tachycardia, hypertension and dysrhythmias. Various techniques and drugs have been tried to attenuate this circulatory response. Material and Method 120 ASA Grade I and II patients of either sex ,aged between 25- 60 years, weight ranging from 50-60 kg undergoing elective surgical procedures under general anaesthesia were divided in 2 groups through random allocation. Group allocation and study design GroupA: Received oral clonidine 150 mcg 60 minutes before induction. Group B: Received oral atenolol 25 mg 2.5 hours before induction . Haemodynamic parameters were recorded at preinduction, postinduction, during laryngoscopy and 1,3,5 and 15 minutes after laryngoscopy. Results Heart rate decreased after giving tablet clonidine and tablet atenolol in both the groups. Increase in heart rate at T1 in clonidine group A took more than 10 minutes to return to baseline, However, heart rate remained below the baseline in atenolol group except at 1 min when transient rise was seen in the atenolol group.Haemodynamic parameters are fairly attenuated by atenolol as compared to clonidine.