Volume : 8, Issue : 2, February - 2019

PATTERN OF HEMOGLOBINOPATHIES AND THALASSEMIAS.

Dr Parvez Bahar Choudhury, Dr Rupjyoti Gogoi

Abstract :

Thalassemia and other structural haemoglobinopathies are the major genetic disorders prevalent in certain parts of the world including India. Aims: To study the pattern of different haemoglobin disorders .Methods: In this retrospective study, we included all the cases referred to our centre, for High performance liquid chromatography(HPLC) using BIORAD D 10 system. Results: Out of total 500 referred cases , 225 (45%) were detected to have abnormal haemoglobin. The commonest disorder was Hb E trait(145 cases),followed by Hb E disease(39 cases),B Thalassemia trait(20 cases),Compound heterozygous for Hb E and beta thalassaemia (15 cases), Beta thalassaemia major(03 cases),Hb S trait(03 cases) . Conclusion: This study provides a comprehensive database on the spectrum of haemoglobinopathies . HPLC was found to be a simple, rapid and reliable method for the detection of hemoglobin variants