Volume : 3, Issue : 6, June - 2014

Antitumor Effect of Phyllanthusniruri on Irradiated Breast Cancer Tissue in Rat Through Activation of IFNY and CD95

Bambang Soeprijanto, Juliati Hood Assegaf

Abstract :

This study aims to investigate whether the aqueous extract of Phyllanthusniruri administered orally contribute to the antitumor effect onirradiated east cancer in rats.Interferrongamma(IFNγ)and cluster of differentiation 95 (CD95)had beenknown to haveantitumoreffects.An experimental study was carried out in rat with east cancer induced by the 7.12–Dimethylbenz (a) anthracene (DMBA) and then irradiated (6Gy). The research sample were divided randomly in 3 groups (pretest, treatment and control). Each group had 10 rats. The treatment group was given the plant extract orally (250 mg/kg. b. wt). A significant increase in the number of cells expressing IFNγ(p<0.05) and a significant increase in the number of cancer cells expressing CD95 (p<0.05) in the treatment group were observed. The result indicated that oral administration of Phyllanthusniruri extract increased the antitumor effect on Irradiated east cancer in rats through activation of IFNγ and CD95.