Volume : 4, Issue : 4, April - 2015

Bio-Clinical Study of Envenomed victims in Osmania General Hospital, Hyderabad.

Dr. C. R. Ram Reddy, Dr. C. R. Vijay Bharath Reddy

Abstract :

<p>&lt;p&gt;&amp;lt;p&amp;gt;&amp;amp;lt;p&amp;amp;gt;&amp;amp;amp;nbsp;Background &amp;amp;amp;amp; Objectives: Every year there are about one lakh cases of snake bite deaths all over the world, mostly either&amp;amp;amp;nbsp;&amp;amp;lt;/p&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;with coa, viper or krait snakes. Nearly about 1/3rd of them are reported in India. Still most of the rural population of&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;India needs awareness regarding envenomation management. About 40% of snake bitten victims are losing their lives&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;ignorantly due to delayed hospitalization and indulging in unscientific management. Sole object of this study is to project and impress upon the&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;scientific management through clinical evaluation, study of bio&amp;amp;amp;ndash;clinical samples with subsequent treatment of envenomed victims.&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;Methods:&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;Various types of data concerning 276 snake bite victims both live and dead cases were collected from retrospective, prospective and follow&amp;amp;amp;ndash;up&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;cases for coa bite detection during the period from 1999 to 2000. The live cases are followed clinically in the casualty, medical wards and ICU.&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;Dead victims are examined in the mortuary of Osmania General Hospital, Hyderabad; A.P. Antibodies against coa venom are raised while&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;conducting animal experimentations (rabbits and goats) and subjected the anti body sera to ELISA test against bio&amp;amp;amp;ndash;samples of victims. Live bioclinical samples collected from the clinical wards are bitten area washings, blood, urine and cereo spinal fluid (csf) for further investigations.&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;From the mortuary snake bite victim&amp;amp;amp;rsquo;s autopsy samples like skin bit, blood from right ventricle, liver and kidney are collected. All the samples are&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;subjected to ELISA, histopathological examination and other routine investigations.&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;Results:&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;The results obtained in this study of envenomed victims of live and dead are analyzed, compiled and compared and they are found to be satisfied&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;in their respective criterions. The same results are further strengthened with the observations of previous scientific studies mentioned later in the&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;discussion part.&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;Conclusion&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;The clinical evaluation, biochemical and histopathological examination of all snake bite cases living and dead under the study have shown much&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;convincing and corroborating evidences with one another. The results of the study are very much comparable and are consistent with previous&amp;amp;amp;nbsp;&amp;amp;lt;/div&amp;amp;gt; &amp;amp;lt;div&amp;amp;gt;scientific observations as expressed in discussions.&amp;amp;lt;/div&amp;amp;gt;&amp;lt;/p&amp;gt;&lt;/p&gt;</p>