Volume : 4, Issue : 8, August - 2015

Neurohistological Effects of Lead on Medulla of Adult Albimo Rat

Dr S M Dawar Husain

Abstract :

<p>LEAD is toxic to every organ of body, including central nervous system. This study is aimed to observe the histopathological changes in the medulla of rat induced by oral administration of lead compound in adult albino rats. Total number of 20 adult albino rats of either sex were included in the present study, consisting of equal numbers in both control and experimental groups. Experimental group received 4% aquous lead acetate orally for 15 days, then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Medulla was dissected. 10&micro; thick sections were obtained and were stained with Glees Silver stain. Under light microscope, medulla from experimental group revealed not much conspicuous changes except for comparative lightly stained fibers and a little swollen tract areas. It was concluded that lead has toxic effects on the central nervous system including medulla which may explain the clinical manifestation of lead neurotoxicity</p>