Volume : 2, Issue : 1, January - 2013

Lipid abnormalities in breast cancer of women

Dr. Amit Kakaiya, Dr. Gaurav Modi, Dr. Aarti Kakaiya, Dr. N Haridas, Dr. Tejas Shah

Abstract :

Breast cancer is one of the most prevalent cancers in women with fatal outcome. Associations between lipids, lipoproteins and cancer have been studied by many workers in the past but reports were contradictory and inconclusive. Thus we sought to evaluate lipid abnormalities in east cancer of women and its link to carcinogenesis. Total 54 untreated east cancer women and 54 apparently healthy women as control were enrolled. They were investigated for serum triglycerides (TGs), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL). Cancer stages, age groups and menopausal status were undertaken for the study. In premenopausal patients, serum HDL was found significantly lower but other parameters were not significantly associated. In postmenopausal patients, TC and HDL were significantly lower while serum TGs and VLDL were significantly higher. No change was observed in LDL levels. It is concluded that east cancer women have characteristic lipid abnormalities in the form of hypertriglyceridemia, raised VLDL and lower HDL levels which may explain their role in carcinogenesis.