Volume : 5, Issue : 3, March - 2016

Relationship between age and Crohn�s disease phenotype in patients admitted at Gujarat Adani Institute of medical science, Bhuj, Kutch, Gujarat

Dr Kamlesh Vegad, Dr Rajesh Gouri

Abstract :

<p>&nbsp;Objective: to compare disease behaviour in patients with Crohn&rsquo;s disease (CD) based on age at diagnosis. Methods: behavior was characterized according to the Montreal classification. Patients with either stricturing or penetrating disease were classified as having complicated disease. Age at diagnosis was categorized as &lt;17, 17&ndash;40, 41&ndash;59 and &ge;60 years. Logistic regression analysis was performed to examine the association between advanced age &ge;60 and complicated disease. Results: A total of 467 patients were evaluated in Gujarat Adani Institute Of Medical Science From April 2013 and may 2015. Increasing age of diagnosis was negatively associated with complicated disease and positively associated with colonic disease. As age of diagnosis increased, disease duration, family history of Inflammatory bowel disease and perianal disease decreased. After adjustment for confounding variables, the association between age at diagnosis and complicated disease was no longer significant (OR: 0.60, 95% CI: 0.21&ndash;1.65). Conclusions: patients diagnosed with CD &ge;60 were more likely to have colonic disease and non-complicated disease. However, the association between age at diagnosis and complicated disease did not persist after adjustment for confounding variables.</p>