Volume : 5, Issue : 10, October - 2016

A COMPARATIVE STUDY OF THE EFFICACY OF TRANEXAMIC ACID AND MEFENAMIC ACID WITH AND WITHOUT ETHAMSYLATE IN THE MANAGEMENT OF DYSFUNCTIONAL UTERINE BLEEDING

Dr. M. Damadari Bai

Abstract :

<p>&nbsp;Introduction: Dysfunctional uterine bleeding (DUB) is responsible for more than 1/3rd of all admissions in the gynecological outpatient clinics. Menorrhagia is defined as a complaint of heavy menstrual bleeding over several consecutive cycles and affects upto 11% of women in their reproductive age group. Aims&amp;Objectives: To study the efficacy of Antifiinolytic drugs and Antiprostaglandin drugs when combined with Ethamsylate in the management of DUB. Materials &amp; Methods: This study is randomized prospective study which was done in the Department of Obstetrics and Gynecology, Government Maternity Hospital, Hanmakonda / Kakatiya Medical College, Warangal after due approval of the ethical committee of medical college. A total of 50 patients were studied in each group with age between 15-50 years and they were divided into groups each of (A&amp;B) 25 patients. Results: There is subjective reduction in bleeding (Menorrhagia, Polymenorrhagia) .In group A (75%) subjective symptoms of reduced bleeding by the patients gave better results when compared to Group B(60%). There is no change in 25% of patients in Group A and 40% in Group B. There is reduction of pallor within 8 weeks in Group A( more pronounced), when compared to Group B (9 Weeks).In Group A average Hb% before Treatment is 8.7gm%, After treatment for 3 cycles it is 13.5gm% and in Group B it is 8.9gm% before treatment and 12.8gm% after treatment. p value is &lt;0.001 in both groups which is highly significant. Conclusion: The management of DUB has undergone a drastic change after the evidence based medicine studies done by Cochrane. As it is now recognized as a clinical entity Combination of Tranexamic acid with mefenamic acid and ethamsylate for the management of DUB</p>