Volume : 5, Issue : 11, November - 2016

A COMPARATIVE RANDOMIZED STUDY ON THE HEMODYNAMIC EFFECTS OF OXYTOCIN IV BOLUS VERSUS INFUSION IN CAESAREAN SECTION

Pratheeba Durairaj, Vasukinathan Arokyamuthu, Edward Johnson Joseph, Dipin Mani

Abstract :

<p>&nbsp;Objective: To compare the hemodynamic effects of oxytocin IV bolus versus infusion during caesarean section, and to analyze the occurrence of side effects with either method. Methods: 60 ASA II pregnant patients posted for elective Lower Segment Cesarean Section were randomly assigned to receive either IV Bolus 5 units of oxytocin (Group B) or IV Infusion of 40 units of oxytocin in 500 ml of normal saline (Group I) following delivery of the fetus. All patients included in the study received spinal anesthesia. Hemodynamic parameters were measured preoperatively, intraoperatively and post operatively. Any side effects were watched for throughout this period. Results: The systolic blood pressure, diastolic blood pressure and mean arterial pressure were significantly lower in the bolus group compared to the infusion group during the first 10 min following administration of the drug. Pulse rates were significantly higher in the bolus group. The adverse effects like chest discomfort, vomiting and ECG changes were reported in bolus group. Need for additional oxytocin doses and other uterotonics were higher in the infusion group compared to the bolus group. Conclusion: Bolus doses of oxytocin produce significant hypotension and tachycardia, and other adverse effects compared to infusion but produce better uterine contractility</p>