Volume : 5, Issue : 11, November - 2016

THE EFFECT OF TRANEXAMIC ACID IN CONTROLLING PERI OPERATIVE BLOOD LOSS:

Dr B Ravi, Dr Saranya Ravi

Abstract :

<p>&nbsp;TRANEXAMIC ACID IS AN ANTI FIBRINOLYTIC DRUG USED FOR PROMOTING CLOT FORMATION IN THE SETTING OF MASSIVE HAEMORRHAGE WITH SUSPECTED NEED FOR MASSIVE BLOOD TRANSFUSION(CLINICAL EVIDENCE OF MARKED BLOOD LOSS-INTERNAL OR EXTERNAL,SUSTAINED TACHYCARDIA AND HYPO TENSION. ) TRANEXAMIC ACID IS CONTRA INDICATED IN NON HAEMORRHAGIC SHOCK,NON TRAUMATIC BLOOD LOSS AND HAEMORRHAGIC LOSS STABILISED WITH OTHER HAEMOSTATIC AGENTS/MEASURES. THE EXACT TIME OF ONSET IS NOT CLEAR AFTER INTRA VENOUS ADMINISTRATION WITH DELAYED EFFECTS UPTO 48 HOURS CONSISTENT WITH ANTI INFLAMMATORY ACTIONS.IT&rsquo;S THEORETICAL CONCERN ,TXA HAS NOT BEEN SHOWN TO CAUSE SIGNIFICANT INCREASE IN DVT,PULMONARY EMBOLISM,MYOCARDIAL INFORCTION OR STROKE IN PUBLISHED TRIALS TO DATE.TXA IS ADMINISTERED AS 1 GRAM IV OVER 10 MINUTES IN 100 ML OR 250 ML NORMAL SALINE</p>