Volume : 5, Issue : 12, December - 2016

Assessment Of Use Of Fixed Dose Combinations In Indoor Patients Of Medicine Department Of A Tertiary Care Hospital In India

Dr. Abhishek Ghosh, Surjeet Kumar Malakar, Sunrita Das, Rajshree Jha

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,serif">Background:</span></b><span style="text-align: justify; font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"> Use of FDCs is associated with increased efficacy, reduced pill burden and cost of therapy and hence better patient compliance but they have certain disadvantages too. Some FDCs are used despite having no advantage. This study aimed to assess use of FDC in indoor patients of Medicine department of a government hospital.</span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,serif">Methods:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"> Total 615 patients bed head tickets were analyzed and </span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;">total number of FDC out of all prescription drugs were analyzed, expressed in the percentage. Number of FDC present in WHO and National essential medicine list of India were calculated.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,serif">Results:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"> Overall 4547 drugs&nbsp; were prescribed among all patients, out of which 484 were FDCs (10.64%&nbsp; of all drugs). number of FDC s prescribed per patient was 0.79.&nbsp; Out of 484 FDC, 71 combination drugs are included in National list of essential medicine 2015 and 52 are from WHO essential medicine list. 17 FDC (3.51%) were from the list which are irrational or banned combination as per recent notification by DCGI in 2016.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,serif">Conclusion:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"> Continuous medical education is necessary to make Physicians aware of this and they should be encouraged to write more combination drugs from the essential medicine list and avoiding writing irrational combinations.<o:p></o:p></span></p>