Volume : 6, Issue : 1, January - 2017

Congenital Malformations Of Heart In Perinatal Autopsies.

Md. Ibrahim Siddiqui, Anita A. M, Sainath K. Andola, Anuradha G. Patil

Abstract :

<p>&nbsp;<b><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif;text-transform:uppercase">Background</span></b></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">Congenital malformations remain a common cause of perinatal deaths and even though ultrasonogram can give fairly accurate diagnosis, perinatal autopsy is essential to confirm the diagnosis and look for associated malformations.</span><span style="font-family:&#10;&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><b><span lang="FR" style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif;text-transform:uppercase;&#10;mso-ansi-language:FR">Objectives</span></b><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">To emphasize the importance of perinatal autopsy in diagnosing congenital malformations of&nbsp; heart and to study the distribution of congenital malformations of&nbsp; heart in perinatal deaths.</span><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><b><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif;text-transform:uppercase">Materials and Methods</span></b><a name="_GoBack"></a><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;The present study comprised 100 hearts from consecutive perinatal autopsies conducted in Department of Pathology, M.R Medical College, Gulbarga, over a period of 1year. </span><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">The protocol included the removal of thoracic, cervical, abdominal and pelvic organs en block and subsequently dissected into organ blocks. Histological sections were taken from heart, lung, liver, kidney, thymus, ain, placenta and umbilical cord. </span><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><b><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif;text-transform:uppercase">Results</span></b><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">Out of 100 cases, 05 cases (5%) showed congenital malformations of heart with M : F&nbsp; 1.5:1. Majority of cases with heart malformations were IUDs (60%) with maximum 03 cases between 30-34 weeks; mean Gestational age 31weeks and mean gestational weight between 2000grams. Most common congenital malformation was VSD (3 cases) followed by one case each of ASD and TGA. 01 case (ASD) presented as part of&nbsp; Edward&rsquo;s syndrome.</span><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><b><span lang="IT" style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif;text-transform:uppercase;&#10;mso-ansi-language:IT">Conclusion</span></b><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="Body" style="line-height:120%"><span style="font-size:12.0pt;&#10;line-height:120%;font-family:&quot;Times New Roman&quot;,serif">This study highlights the importance of perinatal autopsy in confirming the diagnosis of congenital anomalies by prenatal ultrasound findings.</span><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>