Volume : 6, Issue : 3, March - 2017

A Case Control Study of Heart Rate Variability in Rheumatoid Arthritis female patients

Dr Sadhana Agrawal, Dr Jyotsna Shukla, Dr Deepak Goyal, Dr Suraj Prakash Indoria, Dr Aradhana Singh, Dr Arvind Kumar Shukla

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">Background &ndash; In Rheumatoid Arthritis (RA) patients&rsquo; involvement of autonomic nervous system has rarely been studied</span><sup style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">1</sup><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt; text-align: justify;">.</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Objective &ndash; </span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,serif;mso-fareast-font-family:KeplerStd-Italic;mso-bidi-font-style:&#10;italic">Evaluation of cardiovascular autonomic neuropathy (CAN) by the mean of heart rate variability (HRV) in RA patients.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Material and methods &ndash; 45 RA female patients (age group 35-45 years) along with 45 age and BMI matched female controls were evaluated by Frequency domain HRV parameters : TP (ms² ) ;LF (ms² ); HF (ms²); LF n.u. (%); HF n.u. ( %) and LF/HF ratio recorded by Polyrite D based on EKG. Statistical analysis was performed using SPSS software version 20 and Z-test was used to derive the level of significance.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Results &ndash; </span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&quot;Times New Roman&quot;">The mean TP (</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,serif">ms²</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">) with p value &lt; 0.05, mean HF (</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">ms²</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">) and mean HF </span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">n.u. (%) with</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:&quot;Times New Roman&quot;">&nbsp; p value &lt;0.001 were found significantly lower whereas mean LF </span><span lang="EN-IN" style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,serif">n.u. (%)</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"> and LF/HF ratio with p value&lt;0.001were found significantly higher in RA patients as compared to control group.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Conclusion&ndash; Decreased Heart rate variability indicates </span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;&#10;mso-fareast-font-family:KeplerStd-Italic;mso-bidi-font-style:italic">deranged cardiovascular autonomic functions in RA patients.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>