Volume : 6, Issue : 4, April - 2017

Evaluation of plasma fibrinogen levels in diabetes mellitus and its correlation with HbA1c levels.

Metan Sb

Abstract :

<p>&nbsp;Background Diabetes mellitus comprises a group of common metabolic disorder where increased fiinogen level can act as a thrombogenic factor. Diabetic patients have higher cardiovascular morbidity than non diabetic subjects. Several studies have shown that haemostatic &nbsp;factor especially hyperfiinogenaemia is implicated as a source of atherosclerosis. Material and method : A &nbsp;study was conducted to compare fiinogen levels between 30 type 2 diabetes patients and 10 age and sex matched healthy controls. Their&nbsp; fiinogen levels are compared and correlated with &nbsp;risk factors like glycosylated&nbsp; haemoglobin ,age ,sex ,smoking ,body mass index(kg/m2),and hypertension. Results : It was seen that in diabetic patients ,the plasma fiinogen levels were higher than non diabetic even though it was not statistically significant.(327.37 &plusmn;47.25 vs 327.1&plusmn;72.45: p &gt; 0.05) . The study re established co relation between HbA1c&nbsp; and fiinogen levels of the diabetic patient is positive i.e.,poorer the glycaemic status ,higher the fiinogen levels .(r=0.21). Conclusion : &nbsp;It can be concluded that fiinogen levels are increased in diabetic subjects which is associated with glycemic index .This contributes to the excess cardiovascular morbidity and mortality.</p>