Volume : 6, Issue : 6, June - 2017

IMMUNOEXPRESSION OF CYCLIN D1 AND KI-67 IN HYPERPLASTIC AND NEOPLASTIC ENDOMETRIUM

Dr. Amit Pal, Dr. Priyanka Mondal, Dr. Sudipta Chakraborti, Dr. Jayati Chakraborty

Abstract :

<p>&nbsp;<b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Background-</span></b><span style="font-size: 14pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">various cell cycle promoting and inhibiting factors have important role in proliferation and differentiation of malignant cells</span></p> <p class="MsoNormal"><b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Aim-</span></b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">The study was done to examine the expression of cell cycle regulatory protein Cyclin D1 in endometrial hyperplasias &nbsp;and endometrial carcinomas in a quantitative manner &amp; to assess correlations of Cyclin D1 expression with Ki-67 ,a proliferation marker.<o:p></o:p></span></p> <p class="MsoNormal"><b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Materials and methods-</span></b><span style="font-size:14.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,serif"> We evaluated and compared the expression of Cyclin D1 and Ki-67 in 50 endometrial samples submitted as either endometrial curetting or hysterectomy specimens, which were diagnosed as Hyperplasia without atypia(<i>n </i>= 23), atypical hyperplasia (<i>n </i>= 16), and endometrial carcinoma (<i>n </i>= 11).<o:p></o:p></span></p> <p class="MsoNormal"><b><span style="font-size:14.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,serif">Results-</span></b><span style="font-size:&#10;14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif;mso-bidi-font-weight:&#10;bold"> </span><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">There was increased expression of Cyclin D1 and Ki-67 in patients with endometrial carcinoma compared to endometrial hyperplasia. Cyclin D1 expression had a positive correlation with Ki-67 expression.<o:p></o:p></span></p> <p class="MsoNormal"><b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">Conclusion-</span></b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"> Cyclin D1 together with Ki-67 may be used as a marker for endometrial carcinogenesis and tumor cell proliferation.<o:p></o:p></span></p>