Volume : 6, Issue : 7, July - 2017

A STUDY COMPARING TWO DOSES OF ROCURONIUM WITH SUXAMETHONIUM FOR INTUBATION IN CHILDREN IN 60 SECONDS

Dr Muthushenbagam, Dr K Premakumari

Abstract :

<p>&nbsp;<b style="text-align: justify;">Background and goals of study</b><span style="text-align: justify; line-height: 150%;">: </span><span class="normaltextrun" style="text-align: justify;">Succinylcholine is an ultra short acting depolarizing muscle relaxant, but has many undesirable side effects, some of which may be life threatening.</span><span class="eop" style="text-align: justify;">&nbsp;</span><span class="normaltextrun" style="text-align: justify;">Rocuronium omide is a steroidal non-depolarizing neuromuscular blocker with a rapid onset and may be a suitable alternative to succinylcholine for rapid control of airway. Comparison of the two drugs in terms of intubating conditions, hemodynamics and adverse effects is important.</span></p> <p class="paragraph" style="margin-left:4.5pt;text-align:justify;line-height:&#10;150%;vertical-align:baseline"><b>Methods</b><span style="mso-bidi-font-size:14.0pt;&#10;line-height:150%">: Sixty patients were grouped into three groups of twenty each in this randomised, prospective, parallel group study. </span>Group &mdash; I (R6) Thiopentone 5mg/kg + Rocuronium 0.6mg/kg, Group &mdash;Il (R9) Thiopentone 5mg/kg + Rocuronium 0.9mg/kg, Group-Ill (S) Thiopentone 5mg/kg + Suxamethonium I .5mg/kg. Intubating conditions, hemodynamics and adverse effects are compared.<span style="font-size: 10pt; line-height: 150%;"><o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><b><span style="font-size:12.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">Results</span></b><span style="font-size:12.0pt;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&#10;&quot;Times New Roman&quot;,serif">: The </span><span style="font-size:12.0pt;mso-bidi-font-size:&#10;16.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif">mean score for Jaw Relaxation was significantly higher in Group II and Group III. Mean score for vocal cord position was significantly higher in&nbsp;Group II &amp; Group III when compared to Group I. Mean score for response to intubation was significantly higher in&nbsp;Group II and Group III when compared to Group I. Mean total intubating score in Group II (R9) and Group III (S) were identical which is significantly higher than Group I. The mean heart rate, Systolic Blood&nbsp;Pressure, Diastolic Blood Pressure, Mean Arterial Pressure during intubation in Group I (R6) was higher than in Group II and Group III.</span><span style="font-size:12.0pt;&#10;mso-bidi-font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><b><span style="font-size:12.0pt;mso-bidi-font-size:14.0pt;line-height:&#10;150%;font-family:&quot;Times New Roman&quot;,serif;mso-fareast-font-family:Univers-Medium">Conclusion: </span></b><span style="font-size:12.0pt;mso-bidi-font-size:16.0pt;line-height:&#10;150%;font-family:&quot;Times New Roman&quot;,serif">Rocuronium 0.9mg/kg (3xED95) can be used as an alternative ideal agent to suxamethonium for intubation in children. But while choosing Rocuronium as an alternative to suxamethonium factors such as intubation difficulty and surgical duration should be considered against the potential side effects of suxamethonium.&nbsp;<o:p></o:p></span></p>