Volume : 6, Issue : 6, June - 2017

Profile of Hepatitis B Screening programme in Salem tertiary referral centre

Dr. Rajkumar Solomon, Dr. C. Krishnan, Dr. E. Kandasamy Alias Kumar

Abstract :

<p>&nbsp;<b style="text-align: justify; font-size: 12px;"><i><span lang="EN-IN" style="font-size:10.0pt;&#10;mso-bidi-font-size:12.0pt">Background</span></i></b><span lang="EN-IN" style="text-align: justify; font-size: 10pt;"> : Hepatitis B virus carrier state in the world&nbsp; is&nbsp; estimated to be&nbsp; around 400 million today; 75% of this population&nbsp; live&nbsp; in Asia and the Western Pacific.&nbsp; HBV vaccination programme&nbsp; have been available since the early 1980s. Vertical transmission and early exposures found to&nbsp; be major sources of infection in areas of&nbsp; high-prevalence. Promiscuous heterosexual contact and&nbsp;&nbsp; drug use account for many new cases in young adults. HBV is the main cause of cirrhosis and HCC in the world ,World wide hepatitis B vaccination can&nbsp; have the greatest impact on Hepatitis B&ndash;related mortality in future. Fulminant acute hepatitis B is responsible&nbsp; for thousands of death&nbsp; per year in the United States, and chronic HBV&nbsp; related deaths amounts to&nbsp; one million deaths worldwide each year. Hence population screening for HBV is of paramount importance. <b><i>Aim</i></b>: 1. To identify the HBsAg&nbsp; positive status of the&nbsp; patients&nbsp; attending the out patient Department of Medicalgastroenterology , Government Mohan Kumaramangalam Medical college hospital , Salem. 2. To evaluate the clinical profile of the patients with HBs Ag positive. <b><i>Methods</i></b>: Study Design: prospective study.&nbsp; 1511 Patients and the relatives attending out&nbsp; patient department of Medical gastroenterology GMKMC , Salem were screened for HBsAg&nbsp; with ELISA kits. Period of study :from&nbsp; July2012 to June2013. Subsequently&nbsp; liverfuction tests , HBeAg, HBV DNA quantification by PCR, abdominal ultrasound were done for HBsAg positive patients. Results: of these 1511 persons eight one were tested positive for HBsAg. (5.36%).Number of males:62 Number of females:19. Male: female ratio was 3.26. those who tested&nbsp; positive for HBs Ag were from gaes 12 to 70 years.The HBsAg positive persons were evaluated with liver function tests, abdominal ultrasound , HBeAg,&nbsp; and HBV quatification by PCR method.Family screening was done&nbsp; for HBsAg positive&nbsp; persons. Hepatitis B vaccination was advised for&nbsp; those who tested negative for HbsAg. <b><i>Conclusion</i></b>:Hepatitis B virus screening programme helps in identifying HBV infection in the community. It also helps in assessing the persons who require anti viral therapy</span></p> <p style="text-align:justify"><span lang="EN-IN" style="font-size:10.0pt;mso-bidi-font-size:12.0pt"><o:p></o:p></span></p>