Volume : 6, Issue : 8, August - 2017

Neonatal Sepsis: Bacteriological and drug resistance profile.

Dr. Jyoti B. Bade, Dr. Chhaya Chande

Abstract :

<p>&nbsp;<b><i><span style="font-size:12.0pt;line-height:107%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Aims:</span></i></b><span style="font-size: 12pt; line-height: 107%; font-family: Arial, sans-serif;"> This study was conducted to know bacteriological profile and antimicrobial resistance of isolates from blood cultures received from neonates suspected to have septicemia.</span></p> <p class="MsoNormal"><b><i><span style="font-size:12.0pt;line-height:107%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Material and methods</span></i></b><span style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">: In the present study 784 neonates clinically suspected to have suspected of sepsis admitted in NICU were included. </span><span lang="EN-GB" style="font-size:12.0pt;line-height:107%;font-family:&#10;&quot;Arial&quot;,&quot;sans-serif&quot;;mso-ansi-language:EN-GB"><o:p></o:p></span></p> <p class="MsoNormal"><b><i><span lang="EN-GB" style="font-size:12.0pt;line-height:107%;font-family:&#10;&quot;Arial&quot;,&quot;sans-serif&quot;;mso-ansi-language:EN-GB">Results:<o:p></o:p></span></i></b></p> <p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-ansi-language:EN-GB">Blood culture was positive in 128 (16.32%) cases. Gram positive bacteria 61(47.65%) were responsible for most cases of neonatal sepsis as compared to gram negative bacteria 55 (42.96%). Multidrug resistance was observed in 21(38.18%) Gram negative isolates.<o:p></o:p></span></p> <p><b><i><span lang="EN-GB" style="font-size:12.0pt;line-height:107%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">Conclusions:</span></i></b><span lang="EN-GB" style="font-size:12.0pt;line-height:107%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA"> Rational antimicrobial therapy can be started on time based local epidemiology and resistance pattern. Multidrug resistance in Gram negative isolates warrants great caution in selection of antibiotic therapy</span></p>