Volume : 6, Issue : 8, August - 2017

A COMPARATIVE EVALUATION OF TETRACYCLINE CONTAINING MICROSPHERES AND COMMERCIALLY AVAILABLE TETRACYCLINE FIBERS TO EVALUATE THEIR EFFICACY IN PERIODONTAL POCKET THERAPY - A CLINICAL AND MICROBIOLOGICAL STUDY

Dr. Manish Kumar, Dr. Mona Sharma, Dr. Vivek Govila, Dr. Vineeta Mittal, Prof. Dr. Shailendra K. Saraf

Abstract :

<p>&nbsp;<span style="text-align: justify;">The aim of this clinical trial was to </span><span lang="EN-IN" style="text-align: justify;">compare the efficacy of Tetracycline containing</span></p> <p class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;&#10;text-align:justify;line-height:200%"><span lang="EN-IN">&nbsp;Microspheres (TM) and commercially available tetracycline containing Fibers (TF) as local<o:p></o:p></span></p> <p class="MsoListParagraphCxSpLast" style="margin-left:0in;mso-add-space:auto;&#10;text-align:justify;line-height:200%"><span lang="EN-IN">&nbsp;drug-delivery system in the treatment of periodontal pocket therapy</span>. A randomized split mouth design was adopted&nbsp; for allocating, 50 sites in different treatment modalities : SRP + TF and SRP + TM. Periodontal Plus AB was used for TF group and prepared microsphere containing Tetracycline was used for TM group. Clinical parameters were seen at baseline, 1&nbsp; and 6 months and microbiological analysis was done at baseline and 3 months. Clinical parameters that were recorded were PI, GI, PD and RAL. In microbiological analysis, CFU of Prevotella Intermedia were seen. The result revealed that both &nbsp;groups showed a statistically significant reduction in clinical parameters and microbiological parameters&nbsp; at 1, 3 and 6 months compared to baseline and TM was more effective in comparison to TF.&nbsp;<span lang="EN-IN"><o:p></o:p></span></p>