Volume : 6, Issue : 9, September - 2017

FREE REDICAL INJURY AND OXIDATIVE STRESS: A REVIEW

Prof. Dr Sharique Ahmad, Dr Amina Maqbool

Abstract :

<p>&nbsp;<span style="text-align: justify; font-size: 14pt; letter-spacing: -0.25pt;">Free radical is referred to an atom with a single </span><span style="text-align: justify; font-size: 14pt; letter-spacing: -0.4pt;">unpaired electron, within a biological system free </span><span style="text-align: justify; font-size: 14pt; letter-spacing: 0.7pt;">radicals can react indiscriminately with </span><span style="text-align: justify; font-size: 14pt; letter-spacing: -0.2pt;">neighboring molecule causing extensive cellular </span><span style="text-align: justify; font-size: 14pt; letter-spacing: 0.25pt;">damage which is termed as oxidative stress. Oxidative stress can arise for many reasons </span><span style="text-align: justify; font-size: 14pt; letter-spacing: -0.15pt;">including consumption of alcohol, medications, trauma, cold, air pollutants, toxins and radiation </span><span style="text-align: justify; font-size: 14pt; letter-spacing: -0.25pt;">Air pollutants induced oxidative stress adversely </span><span style="text-align: justify; font-size: 14pt; letter-spacing: -0.3pt;">affects health particularly the pulmonary system.</span></p> <p class="MsoNormal"><span style="font-size: 14pt; line-height: 107%; letter-spacing: -0.35pt;">Ambient air contains a range of pollutants such as </span><span style="font-size: 14pt; line-height: 107%; letter-spacing: -0.15pt;">nitrogen oxide, ozone and particulate materials. </span><span style="font-size: 14pt; line-height: 107%; letter-spacing: -0.2pt;">Out of them ozone derived from photochemical </span><span style="font-size: 14pt; line-height: 107%; letter-spacing: 0.4pt;">smog have the ability to drive free radical </span><span style="font-size: 14pt; line-height: 107%; letter-spacing: 0.15pt;">reactions which gives rise to oxidative stress </span><span style="font-size: 14pt; line-height: 107%; letter-spacing: -0.15pt;">within the lung_ This process initiates responses </span><span style="font-size: 14pt; line-height: 107%;">that are particularly dangerous to susceptible <span style="letter-spacing:-.05pt">population.</span></span><u><span style="font-size:14.0pt;line-height:107%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin"><o:p></o:p></span></u></p>