Volume : 6, Issue : 11, November - 2017

A study on Role of HBV vaccination in chronic liver disease

Dr. Rajkumar Solomon T, Dr. G. Thiyagarajan, Dr. Kandasamy Alias Kumar. E

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span lang="EN-IN" style="font-size:10.0pt;&#10;mso-bidi-font-size:11.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aim</span></b><span lang="EN-IN" style="text-align: justify;">: </span><span lang="EN-IN" style="text-align: justify; font-size: 10pt; line-height: 115%; font-family: &quot;Times New Roman&quot;, serif;">To evaluate the need of HBV vaccination in chronic liver disease patients..<b>Materials and Methods</b>:One hundred consecutive alcoholic patients (Males98: Female 2)with decompensated </span><span lang="EN-IN" style="text-align: justify; font-size: 10pt; line-height: 115%; font-family: &quot;Times New Roman&quot;, serif;">&nbsp;Chronic liver disease patients who attended the department of Medical gastroenterology ,Government Mohan Kumaramangalam Medical college Tamilnadu,India</span><span lang="EN-IN" style="text-align: justify; font-size: 10pt; line-height: 115%; font-family: &quot;Times New Roman&quot;, serif;">were screened in a period of six months for HBsAg, Anti HBc , anti HCV and HIV, apart from the routineinvestigations like &nbsp;complete hemogram, liver function&nbsp; tests, PT INR, alpha feto protein, ultrasound abdomen andportal venous doppler.Patients were between 20 and 64 years of age.<b>Results:</b> Thirteen patients tested positive for HBV (11 HBsAg and 2 HBsAg negative but Anti HBc positive) and 10 patients were anti HCV positive. None were positive for both HBV and HCV. No one was HIV positive. Other causes of chronic liver disease were ruled out, namely metabolic syndrome and diabetes mellitus, autoimmune hepatitis, Wilson disease,etc. <b>Conclusion</b>:Although it is a known fact that patients with alcoholic liver disease (chronic) also test positive for HCV, in this study it has been shown that a substantial number of patients tested positive for HBV also. Hence vaccination against HBV is appropriate for patients with chronic liver disease who test negative for HBV at the time of diagnosis.</span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p>