Volume : 6, Issue : 11, November - 2017

A COMPARATIVE STUDY OF ROLE OF ORAL IRON CHELATORS AND CERTAIN ANTIOXIDANTS IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDILAL INJURY IN ALBINO RABBITS

Dr. Ambrish Kumar Gupta, Dr. Neet Lakhani, Dr. Gaurang Pandey, Dr. Praveen Katiyar

Abstract :

<p>&nbsp;<span style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif;">Coronary heart disease is one of the important causes of mortality worldwide. Though reperfuson in time reduce the infarct size and else but this reperfusion in itself sets off a chain of myocardial damage either due to oxidative damage or altered calcium metabolism. Coronary perfusion has been taken as a measure of recovery from this reperfusion injury. The hearts of albino rabbits have been perfused through </span><span lang="EN-IN" style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif;">Langendorff method and then artificial ischemia has been created followed by reperfusion. </span><span style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif;">Thus antioxidants like oral iron chelators (deferasirox) and allopurinol have been tried for their protective role from this injury.&nbsp; The coronary perfusion has been observed to be enhanced in rabbits on deferasirox or allopurinol, with former having an upper hand.</span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p>