Volume : 6, Issue : 12, December - 2017

A Comparative Study on Minimum Intubating dose of Succinylcholine

S. N. Gupta, R. K. Mehta, Rajeev Kumar, Neeraj Arora, Swati Trivedi

Abstract :

<p>&nbsp;<b><u>BACKGROUND</u></b></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Succinylcholine remains the gold standard and satisfactory muscles relaxants for endo tracheal intubation. <o:p></o:p></span></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The aims of this study to assess three minimum dose of Succinylcholine for tracheal intubation as the modern balance anaesthesia consist of amnesia, analgesia &amp; muscles relaxation. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:12.0pt;line-height:140%"><b><u>MATERIAL &amp; METHODS</u></b><b><u><span style="font-size:11.0pt;line-height:140%;mso-bidi-font-family:Arial"> <o:p></o:p></span></u></b></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 60 adults patient of ASA grade I &amp; II posted for elective surgery under general anaestheisa who also required endo tracheal intubation, was induced with inj. fentanyl, &nbsp;2 mcg / kg.&nbsp; and propofol 2 mg / kg. iv. <o:p></o:p></span></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The patient were randomly allocated in to three groups according to dose of succinylcholine [0.4 mg/kg., 0.6 mg/kg. &amp; 1 mg/kg.]. The overall intubation condition assessed after 60 seconds of succinylcholine inj. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:12.0pt;line-height:140%"><b><u><span style="font-size:13.0pt;&#10;mso-bidi-font-size:11.0pt;line-height:140%;mso-bidi-font-family:Arial">R&shy;ESULT<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The acceptable intubating condition (excellent &amp; good grade combined) were obtained in 65%, 100%, 100% of the patient who received 0.4 mg, 0.6 mg &amp; 1 mg/kg of Succinylcholine respectively, P&lt;0.001, excellent intubation condition were obtained in 51%, 96% and 100% of the patient after 0.4, 0.6 and 1 mg/kg of Succinylcholine respectively P&lt;0.001.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:12.0pt;line-height:140%"><b><u>CONCLUSION <o:p></o:p></u></b></p> <p class="MsoNormal" style="line-height:140%"><span style="font-size:11.0pt;&#10;line-height:140%;mso-bidi-font-family:Arial">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The 0.6 mg/kg Succinylcholine can be used as minimum intubating dose as it provide acceptable intubating condition within 60 seconds as compared to 1 mg / kg which may be excessive. Duration of action of Succinylcholine is dose dependent &amp; reducing the dose allow a more rapid return of spontaneous respiration, reflexes and decreases the apnoea time.&nbsp;<o:p></o:p></span></p>