Volume : 7, Issue : 1, January - 2018

STUDY OF HAEMATOLOGICAL AND COAGULATION PROFILE IN PATIENTS WITH GASTROINTESTINAL MALIGNANCIES

Dr Bhubaneswar Saikia, Dr Rosy Khandelia

Abstract :

<p>&nbsp; Background: Gastrointestinal (GI) Malignancy is one of the commonest malignancies encountered in developing countries. The goal of this study was to analyze the haematological and coagulation profile- Complete Blood Count (CBC), Prothrombin time (PT), activated partial thromboplastin time (aPTT) among patients of gastrointestinal malignancies. Materials and Methods: Fresh blood samples were collected from the diagnosed patients with appropriate anticoagulant in proper proportion. Complete blood count was done by automated analyzer. Peripheral blood smear was seen in cases with abnormal results on CBC. Peripheral smears were stained with Leishman&rsquo;s stain using standard procedures and then examined under light microscope. Results: A total of 30 patients with gastrointestinal malignancy were included in this study. There were 19 males and 11 females. Among all cases of gastrointestinal malignancy, stomach cancers constitute the maximum (50%) followed by rectal cancers accounting for 23.3%. GI malignancy had negative impact on haemoglobin profile, affecting 56.6% of cases. In peripheral smear study, microcytic hypochromic anaemia was most common comprising 63.3% of cases. Regarding leukocyte count, 16(53.3%) cases had leukocytosis,07 have normal leukocyte count,7 had leukopenia. Out of 30 cases, 56.6% had normal thrombocyte count, 30% had thrombocytopenia and 13.3% had thrombocytosis. Out of 30 cases, 60% cases had the normal prothrombin time and 40% cases had values higher than the reference value. Regarding activated partial thromboplastin time (aPTT), 63.3% cases had normal reports and 36.6% cases had values higher than the reference value. Conclusion: Reduced haemoglobin, increase in neutrophil count, change in coagulation profile are associated with poor prognosis in patients with GI malignancy. Hence close monitoring of haematological and coagulation profile in patients with gastrointestinal malignancy will help in reducing morbidity and mortality.</p>