Volume : 7, Issue : 1, January - 2018

Study on Prevalence of Dengue fever in a tertiary care Hospital, South India

Swarna. S, Lallitha. S, Amuthan. M, Ganesan. M, Rajkumar. M, Dhanasezhian. A, Sekhar. R, K. M. Mythreyee

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;&#10;line-height:115%">BACKGROUND</span></b><span style="font-size:12.0pt;&#10;line-height:115%">: <span style="mso-spacerun:yes">&nbsp;</span><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%">Dengue is an acute feile arboviral <span style="mso-spacerun:yes">&nbsp;&nbsp;</span>illness affecting the tropical<span style="color:red"> </span>and sub tropical regions of the world. It is<span style="mso-spacerun:yes">&nbsp; </span><span style="mso-spacerun:yes">&nbsp;</span>one <span style="mso-spacerun:yes">&nbsp;</span><span style="mso-spacerun:yes">&nbsp;</span>of the most important causes of morbidity and mortality <span style="mso-spacerun:yes">&nbsp;&nbsp;</span>in India. This study was done to find out <span style="mso-spacerun:yes">&nbsp;&nbsp;</span>the <span style="mso-spacerun:yes">&nbsp;</span><span style="mso-spacerun:yes">&nbsp;</span>prevalence of dengue virus <span style="mso-spacerun:yes">&nbsp;</span><span style="mso-spacerun:yes">&nbsp;</span>infection and its <span style="mso-spacerun:yes">&nbsp;</span><span style="mso-spacerun:yes">&nbsp;</span>serotype in and around Theni District. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;&#10;line-height:115%">METHODS:<o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%">The study was conducted at Government Theni Medical College (GTMC), Theni, during January 2015 to July 2017. Patients with symptoms of dengue fever attending <span style="mso-spacerun:yes">&nbsp;</span>GTMC hospital were included for the study. Serum samples were tested for dengue NS1 antigen and IgM antibodies by ELISA. Out of 1292 samples, 989 were tested for IgM<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>and 303 were tested for NS1 antigen detection. The NS1 positive samples were further subjected to Real Time PCR for the identification of dengue serotypes.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;150%">Results:<o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%">Dengue infection was confirmed in 520<b style="mso-bidi-font-weight:normal"> </b>(40.25%) cases<span style="mso-spacerun:yes">&nbsp; </span>which <span style="mso-spacerun:yes">&nbsp;</span>include 383 IgM positives and 137 NS1 positives. Paediatric patients were found to be the <span style="mso-spacerun:yes">&nbsp;</span>predominant 390 (75%)] propotion among the dengue cases, whereas adults accounts for only <span style="mso-spacerun:yes">&nbsp;</span>130(25%)., Circulation of all four dengue serotypes were detected in our region with predominance of serotype 1. <span style="mso-spacerun:yes">&nbsp;&nbsp;</span><b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p> <p class="MsoNormal" style="text-align:justify"><b style="mso-bidi-font-weight:&#10;normal"><span style="font-size:12.0pt;line-height:115%">Conclusion:</span></b><span style="font-size:12.0pt;line-height:115%"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%">Dengue infection in our region is documented throughout the year which requires the strengthening of mosquito control program to contain the risk of epidemic during <span style="mso-spacerun:yes">&nbsp;</span>rainy season. <o:p></o:p></span></p>