Volume : 7, Issue : 1, January - 2018

A Comparative Study of free and total Prostate Specific Antigen with Carcino Embryonic Antigen and Alpha Fetoprotein in patients with breast carcinoma ,benign breast disease with healthy individuals in North Bengal Medical College

Suparna Datta, Swati Bhttacharyya, Arup Kumar Banerjee

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin;mso-ansi-language:EN-US">Introduction:</span></b><span style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin;mso-ansi-language:EN-US">Breast cancer is the commonest cancer among women in urban India. The identification of blood biomarkers for early detection of east cancer is an important target of research. Mammography, the current routine method for early detection, has a limited sensitivity for the detection of tumors in dense east tissue . Mammography is available in only few tertiary care hospital in India, so it is not accessible for all patients. Moreover North East India is mostly Hilly region ,so women with east disease can not reach to those hospitals easily, but blood samples can be collected easily through local Health Care Delivery System. A panel of potential cancer biomarkers for east cancer was composed in order to study their combined predictive value for early east cancer.<span style="mso-spacerun:yes">&nbsp; </span>Serum markers such as CEA ,AFP, free and Total PSA were selected for the present study.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin;mso-ansi-language:EN-US">Objective: </span></b><span style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin;mso-ansi-language:EN-US">In the present Study ,an attempt was made to compare efficacy of<span style="mso-spacerun:yes">&nbsp; </span>free<span style="mso-spacerun:yes">&nbsp; </span>&amp; total P.S.A<span style="mso-spacerun:yes">&nbsp; </span>as a tumour marker in east carcinoma in comparison with C.E.A &amp; A.F.P.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Materials &amp; methods: </span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Institution based Observational Case control Study conducted in North Bengal Medical College &amp; Hospital.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Study Population </span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">:- Female patients aged 20-70 yrs has been divided into groups 1. Diagnosed east carcinoma (by biopsy/FNAC), 2. Patients with benign east diseases (biopsy/FNAC) and 3. Healthy control (diagnosed clinically) attending North Bengal Medical College &amp; hospital.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Sample Size</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">:-90 individuals (30 in each group). ELISA performed for all four tumour markers by using standard kit.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Result:</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin"> <b>Serum CEA &amp; tPSA</b> markers are significant in differentiating between benign and carcinoma group. <b>Serum CEA</b> is the only significant marker in differentiating between <b>Normal and Carcinoma</b> group<b>.</b> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Conclusion: </span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;mso-bidi-font-family:Calii;&#10;mso-bidi-theme-font:minor-latin">Serum tPSA &amp; fPSA values are markers of diseased east only. Serum CEA is the only relevant marker in differentiating normal and east carcinoma group<o:p></o:p></span></p>