Volume : 6, Issue : 12, December - 2017

Hepatoprotective and Antioxidant Effects of Ficus Carica against Hepatotoxicity Induced by CCl4 in Rats

Kamel M. A. , El Nabtity S. M. , Hazem T. I.

Abstract :

<p>&nbsp;<b style="text-align: justify;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </b><span style="text-align: justify;">In the view of presumably hepatoprotective potential, effects of water and ether extract of fruits of </span><i style="text-align: justify;">Ficus carica <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">L.</span></i><span style="text-align: justify; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> (Moraceae) </span><span style="text-align: justify;">on some serum biochemical parameters, some antioxidant enzymes and liver histopathological picture on </span><span style="text-align: justify;">CCl</span><sub style="text-align: justify;">4 </sub><span style="text-align: justify;">induced hepatotoxicity in male albino rats were scrutinized. The results had shown significant reduction in enzymatic values of AST, ALT, ALP, GGT, total bilirubin and lipid peroxidation level (LPO) in liver homogenate in </span><span style="text-align: justify;">both water extracts of </span><i style="text-align: justify;">Ficus carica</i><span style="text-align: justify;"> (WEF) and ether extracts of </span><i style="text-align: justify;">Ficus carica</i><span style="text-align: justify;"> (EEF)</span><span style="text-align: justify;"> treated groups when compared to the </span><span style="text-align: justify;">CCl</span><sub style="text-align: justify;">4 </sub><span style="text-align: justify;">administered group</span><span style="text-align: justify;">. Moreover, </span><span lang="EN" style="text-align: justify;">total protein, albumin and globulin </span><span lang="EN" style="text-align: justify;">levels were significantly increased plus</span><span style="text-align: justify;"> antioxidant scavenging capacity was restored through a significant elevation in reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities in liver tissue homogenates in comparison to </span><span style="text-align: justify;">CCl</span><sub style="text-align: justify;">4</sub><span style="text-align: justify;"> administered rats. It was clear from the documented results that </span><i style="text-align: justify;">Ficus carica</i><span style="text-align: justify;"> boasts a hepatoprecautionary role against experimentally induced liver cirrhosis by </span><span style="text-align: justify;">CCl</span><sub style="text-align: justify;">4</sub><span style="text-align: justify;">.&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><o:p></o:p></p>