Volume : 7, Issue : 1, January - 2018

Study of association of leptin and insulin resistance markers in patients of PCOS

Huma Nasrat

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;&#10;text-align:justify;text-justify:inter-ideograph;line-height:150%"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Polycystic ovary syndrome (PCOS)<span class="apple-style-span"><span style="background:white">the most common endocrine disorder , PCOS may present with hirsutism, acne,<span style="mso-spacerun:yes">&nbsp; </span>excessive androgen production, menstrual disturbances and subsequently, anovulation and infertility. <o:p></o:p></span></span></span></p> <p class="MsoNormal" style="line-height:150%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:#231F20">Leptin, a peptide hormone secreted from adipose tissue.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black"> Insulin resistance and hyperinsulinemia may also be factors that affect serum leptin levels.Aim of this study is to evaluate the </span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">association of leptin and insulin resistance markers in patients of PCOS.<o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;margin-right:-16.5pt;&#10;mso-margin-bottom-alt:auto;text-align:justify;text-justify:inter-ideograph;&#10;line-height:150%"><u><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">SUBJECT AND METHOD:</span></u><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Sixty diagnosed cases of PCOS were enrolled in this study after informed written consent. The patients were diagnosed as PCOS as per Rotterdam criteria<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:150%"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">All <span style="mso-spacerun:yes">&nbsp;</span>routine biochemical investigation were done.Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR) and HOMA-beta. HOMA-IR <span style="mso-spacerun:yes">&nbsp;</span>insulin levels and serum leptin levels was measured<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><u><span lang="EN-IN" style="font-size:14.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">RESULT</span></u><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> We found correlation between leptin and various insulin resistance markers although not significant<o:p></o:p></span></p>