Volume : 7, Issue : 1, January - 2018

IRON PROFILE IN PATIENTS OF SICKLE CELL ANAEMIA

Anjali Edbor, Richa

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-US">The inherited disorders of blood include hemoglobinopathies which are one of the major public health problems in India.¹Sickle cell disease is the second most common hemoglobinopathy next to thalassemia in India.³General incidence of Sickle cell disease in India is 1-44%.^{5<b>, 6, 7</b>} The average frequency of hemoglobin S (Sickle cell anaemia) is 4.3 % in India.⁵<span style="mso-bidi-font-weight:bold">In this study we aim to evaluate the iron status in patients of sickle cell anemia</span></span><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-weight:&#10;bold">, </span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-US;mso-bidi-font-weight:bold">to determine the percentage of patients with sickle cell anemia having iron deficiency anemia and to determine iron overload if any in patients of sickle cell anemia. After clearance from Institutional Ethics Committee, patients of diagnosed sickle cell anemia (SS Pattern) were<span style="mso-spacerun:yes">&nbsp; </span>enrolled in the study with their due consent. They were then<span style="mso-spacerun:yes">&nbsp; </span>investigated for complete iron profile i.e.<span style="mso-spacerun:yes">&nbsp; </span>Complete blood count, peripheral blood smear, reticulocyte count with Index, Serum Ferritin, serum Iron, total iron binding capacity, Percentage transferrin saturation. This study was for2 years, from November 2013 to October 2015</span><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-weight:&#10;bold">.</span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-US;mso-bidi-font-weight:bold"> Results:<span style="mso-spacerun:yes">&nbsp; </span>Four patients out of 56 had Iron Deficiency Anemia (7.1%).Three patient had not received blood transfusion, One had received transfusion once. In the study majority of subjects i.e.37 (66.7%) where iron overloaded, which was found more common than iron deficiency. We found 3(5.4%) subjects in whom chelation therapy should be considered. <o:p></o:p></span></p>