Volume : 7, Issue : 1, January - 2018

Annona muricata reduced proliferation caused by Cycas revoluta in Wistar rats

Semassa M. I. Hoteyi, Omedine Koukoui, Loetitia Michodjehoun, Natacha Aivodji, Eudoxie K. Assou, Alphonse Sezan

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;">The purpose of this work is to determine the phytochemic composition of the ethyl extracts of the sheets of <i style="mso-bidi-font-style:normal">Annona muricata</i>, in order to check of them the antineoplasm effects (anti-cancer) on cancer of the liver to the Benin.<span style="color:navy;display:none;mso-hide:all">&para;</span>For this fact, an ethyl extraction using powder of sheets dried of <i style="mso-bidi-font-style:&#10;normal">Annona muricata</i> and ethanol 90&deg; was initially carried out. <span style="color:navy;display:none;mso-hide:all">&para;</span>The screening phytochimic of the sheets of the plant was carried out by the method of Hougton and Raman. <span style="color:navy;display:none;mso-hide:all">&para;</span>And finally the antineoplasm activity (anti-cancer) was evaluated by dosage of the parameters ALAT, ASAT and proteins total on grundings livers of Wistars rats, at the cancer of the liver was armature as a preliminary by exposure to the powder of <i style="mso-bidi-font-style:normal">Cycas revoluta</i> through a diet composed to 5% of this powder and a drink water containing an amount de10mg/kg powder of <i style="mso-bidi-font-style:normal">Cycas revoluta</i>.<span style="color:navy;display:none;mso-hide:all">&para;</span><o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-indent:.5in;line-height:normal"><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;">The results of the screening revealed the presence of several chemical compounds equipped with various properties to varied concentrations. <span style="color:navy;display:none;mso-hide:all">&para;</span>The identified chemical compounds are: <span style="color:navy;display:none;&#10;mso-hide:all">&para;</span>reducing compounds, leuco-anthocyanes, tanins, flavono&iuml;des, coumarins, mucilages and triterpenes. <span style="color:navy;display:none;&#10;mso-hide:all">&para;</span>The antineoplasm activity (anti-cancer) was effective by administration of an amount of 100 mg/kg of ethyl extracts of the sheets of <i style="mso-bidi-font-style:normal">Annona muricata</i>. <span style="color:&#10;navy;display:none;mso-hide:all">&para;</span>This activity showed a variation of intensity according to the mode and the duration of administration of the extracts <span style="color:navy;display:none;mso-hide:all">&para;</span><o:p></o:p></span></b></p>