Volume : 7, Issue : 1, January - 2018

Correlation of Serum Uric Acid and Killip‘s class in patients with Acute myocardial infarction

Dr Amit Shah, Dr Sejal Sejwani

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;vertical-align:baseline"><i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">Background</span></i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">: Acute&nbsp;myocardial infarction (AMI) is a form of ischemic heart disease (IHD) which has emerged as a major contributor to increase in morbidity and mortality. Various studies have found uric acid as a risk factor for cardiovascular disease and a negative prognostic marker for mortality of patients.&nbsp;</span><span lang="EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;vertical-align:baseline"><i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">Aim</span></i><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-IN">: To&nbsp;study if there is any correlation between serum uric acid levels and&nbsp;killips&nbsp;class in patients of acute myocardial infarction.&nbsp;</span><span lang="EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;vertical-align:baseline"><i style="mso-bidi-font-style:&#10;normal"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:EN-IN">Material and Methods</span></i><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-IN">: It was&nbsp;an&nbsp;observational study done for 2 years in a tertiary health care centre, in which 75 patients with AMI were included. Serum UA (Uric Acid) level was measured on day 0, 3 and 7 with&nbsp;uricase&nbsp;method and a detailed history in&nbsp;realtion&nbsp;to&nbsp;killips&nbsp;class was taken. The data collected was analysed to see the pattern of elevation of serum uric acid level and compare it with killips class of patients on days 0,3 and 7.&nbsp;</span><span lang="EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;vertical-align:baseline"><i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">Results</span></i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">: &nbsp;We observed that serum uric acid levels were elevated in patients with acute MI and the levels were almost same on days 0, 3and 7. Patients who had higher killips class also had higher SUA levels. Almost all patients who expired had SUA &gt; 7. </span><span lang="EN-IN"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;vertical-align:baseline"><i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">Conclusion</span></i><span style="font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-IN">:&nbsp;Our study strengthens the previous reports that, serum uric acid could be marker for predicting acute MI-related prognosis and the combination of&nbsp;Killip&rsquo;s&nbsp;class and serum UA level after acute MI could a good predictor of mortality in patients who have acute MI.&nbsp;&nbsp;</span><span lang="EN-IN"><o:p></o:p></span></p>