Volume : 7, Issue : 2, February - 2018

FORMULATION AND IN-VITRO EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF ANTI-PSYCHOTIC AGENT: A SEROTONIN ANTAGONIST-QUETIAPINE FUMERATE

Ms Saniya Khan, Dr M Sunitha, Dr P Shashidhar

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:&#10;text1">The objective of present work is to prepare and optimize extended release tablets of Quetiapine Fumarate which is an atypical antipsychotic agent used in the treatment of schizophrenia, bipolar disorder and major depressive disorder. The peaks of FTIR spectrum of API Quetiapine Fumarate was found to be compatible and no interference with the excipients used in present study. An attempt was made to prepare extended release tablets using Methocel E 50, Sodium Alginate and combination of both as release retarding agents of total 10 trials. </span><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Based on the blend characterization and in vitro evaluation parameters trials T-03 of <span style="color:black;mso-themecolor:text1">Methocel E 50, </span>T-07 of <span style="color:black;mso-themecolor:text1">Methocel E-50 </span>and Sodium alginate T-10 of <span style="color:black;mso-themecolor:text1">Sodium Alginate </span>were taken for optimizing and reproducible trials<span style="color:&#10;black;mso-themecolor:text1"> and based on comparative in-vitro drug release of these three trials, trial T-7 was taken for one month stability studies and determination of order of release rate kinetics. After one month accelerated stability studies, the drug release was found to be 96.33 % in 8 hrs. The order of release was found to be as 0.9954</span> for Koresmeyer Peppas release rate kinetics&gt;<b style="mso-bidi-font-weight:normal">0.9831</b> for Higuchi&rsquo;s model release rate kinetics&gt;<b style="mso-bidi-font-weight:normal"><span style="color:black;mso-themecolor:text1">0.9823</span></b> for Zero order kinetics&gt;<b style="mso-bidi-font-weight:normal">0.8409 </b>for First order kinetics. Based on the results obtained it was confirmed that release of drug from prepared in-house <span style="color:black;mso-themecolor:text1">Quetiapine Fumarate extended release tablets fallows </span>Koresmeyer Peppas with regression coefficient value 0.9954.<o:p></o:p></span></p>