Volume : 7, Issue : 2, February - 2018

ASSESSMENT OF RETINAL NERVE FIBRE LAYER THICKESS IN TYPE II DIABETIC PATIENTS WITHOUT DIABETIC RETINOPATHY BY OPTICAL COHERENCE TOMOGRAPHY

Dr. Sanjeevani Ambekar, Dr. Apurva Puranik

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="line-height:200%"><span style="mso-bidi-font-size:&#10;11.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">In diabetic retinopathy, neuronal loss occurs earlier than microvascular abnormalities. Loss of neuronal tissue will lead to a decrease in RNFL .Any loss of neuronal tissue will lead to a decrease in retinal thickness .. Optical Coherence Tomography (OCT) is the most precise method to measure RNFL.<span style="mso-spacerun:yes">&nbsp; </span>Objective assessment of RNFL will help in developing neuroprotective therapeutic regimens. so that in future, a preventive rather than interventional approach can be applied in its treatment.<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:200%"><span style="mso-bidi-font-size:&#10;11.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">AIM To assess RNFL thickness by OCT in type 2 diabetic patients without DR and compare it with healthy volunteers to detect any nerve fie loss. To correlate RNFL loss with<span style="mso-spacerun:yes">&nbsp; </span>Hb1Ac.<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:200%"><span style="mso-bidi-font-size:&#10;11.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Material &amp;Methods : This is a cross sectional ,observational,<span style="mso-spacerun:yes">&nbsp; </span>descriptive study <span style="mso-spacerun:yes">&nbsp;</span>done on 100 eyes of type 2 diabetic patients without DR and compared with healthy volunteers matched for age and sex<span style="mso-spacerun:yes">&nbsp; </span><o:p></o:p></span></p> <p class="MsoNormal" style="line-height:200%"><span style="mso-bidi-font-size:&#10;11.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Results When avg RNFL thickness of cases was<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>compared with controls significant correlation<span style="mso-spacerun:yes">&nbsp; </span>noted (p-value &lt; 0.05). Significant</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"> correlation was also noted in superior, inferior nasal and temporal quadrants .(p-value &lt; 0.05)<span style="mso-spacerun:yes">&nbsp; </span>.No significant correlation found between<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>RNFL thickness and HB1Ac.<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:200%"><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">CONCLUSION RNFL thinning noted in Type II diabetes patients .<span style="mso-spacerun:yes">&nbsp; </span>Assessment of RNFL thickness can serve as an important tool for early detection and treatment of Retinopathy<o:p></o:p></span></p>