Volume : 7, Issue : 2, February - 2018

DEXMEDETOMIDINE(0.5 �g/kg) IS BETTER THAN CLONIDINE (1 �g/kg) IN ATTENUATING STRESS RESPONSE TO LARYNGOSCOPY AND INTUBATION WHEN USED AS PREMEDICATION IN ADULT SURGICAL PATIENTS

Dr. Santosh Kumar Bhaskar, Dr. Tahir Ali Khan

Abstract :

<p>&nbsp;<b><span style="font-size:11.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">Background and Aims: </span></b><span style="font-size:11.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">The laryngoscopy and endotracheal intubation are known to have profound cardiovascular effects which may increase perioperative morbidity and mortality. The aim of the present study was to compare effects of clonidine &amp; dexmedetomidine to attenuate stress response during laryngoscopy and endotracheal intubation<b>. Methods: </b>In this prospective, randomised, comparative clinical study, one hundred&nbsp; patients of either sex, aged between 20-60 years and American Society of Anesthesiologists ( ASA) physical status I and II were included. Patients were randomly allocated into two groups of 50 patients each. Group 1 received intravenous clonidine 1&micro;g/kg infusion whereas group 2 received intravenous dexmedetomidine 0.5&micro;g/kg infusion, diluted in 200 ml normal saline over 10 minutes.</span><span style="font-size:11.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;TimesNewRoman;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:&#10;AR-SA"> Hemodynamic monitoring as HR, SBP, DBP, MAP and oxygen saturation were noted and compared at different time points as; Before induction, after induction, after laryngoscopy and intubation and&nbsp; 5 minutes after laryngoscopy and intubation.</span><span style="font-size:11.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA"> The statistical analysis was done using Microsoft excel package. <b>Results:</b> The mean heart rate(MHR) in the clonidine group&nbsp; was&nbsp; higher than dexmedetomidine during all&nbsp; observation period,which was statistically significant (P = 0.001).The mean SBP and DBP was significantly lower after intubation and 5 min postintubation in dexmedetomidine group&nbsp; than clonidine group. <b>Conclusion:</b> We conclude that intravenous dexmedetomidine, in doses used in our study, is superior to intravenous clonidine in attenuating the pressor response during laryngoscopy and intubation</span></p>