Volume : 7, Issue : 2, February - 2018

ANTIOXIDANT ACTIVITY OF ADATHODAI CHOORANAM BY IN-VITRO APPROACH

Vethamerlinkumari. H, Karthikeyan. Karu, Nalinisofia. H, Manickavasakam. K, Banumathi. V

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b><span style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="mso-spacerun:yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></b><span style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-weight:bold">The Siddha poly herbal drug Adathodai Chooranam is indicated for respiratory disorders like Bronchial Asthma, onchitis, COPD etc. Bronchial asthma is a clinical syndrome with possible correlation to oxidative stress; therefore the effectiveness of some antioxidant drugs has been studied in management of chronic onchial asthma.</span><span style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> <span style="mso-bidi-font-weight:bold">Antioxidants can compensate the oxidative stress that correlates with asthma, can reduce the symptoms of asthma, and improve pulmonary functions.¹This study was also intended to explore the anti-oxidant activity of the Adathodai Choorananam by in-vitro methods. The antioxidant capacity of the drug was evaluated with the estimation of total Flavonoids, estimation of total phenols, estimation of Vitamin C,</span> <span style="mso-bidi-font-weight:bold">DPPH spectrometric assay, Metal chelating assay, Assay of catalase, Lipid peroxidation assay, and assay of glutathione peroxidase. In DPPH method, 100 &micro;g/ml of the drug and ascorbic acid exhibit 98.9% and77.7% inhibition respectively and the IC 50 value of the drug is <o:p></o:p></span></span></p>