Volume : 7, Issue : 2, February - 2018

ABILITY OF GINGER IN AMELIORATING CHEMOTHERAPY INDUCED NAUSEA IN HEMATOLOGICAL AND SOLID MALIGNANCIES

Mathur Ashwin, Agarwal Vk

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-top:10.0pt;margin-right:0in;margin-bottom:&#10;0in;margin-left:0in;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;&#10;line-height:normal"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Aims and Objectives:</span></b>^{<span style="font-size:13.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;&#10;mso-bidi-language:HI"> <span style="mso-spacerun:yes">&nbsp;</span></span>}<span style="font-size:13.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Effect of ginger on chemotherapy induced side effects were <span style="mso-spacerun:yes">&nbsp;</span>assessed by complete blood counts, renal function test, liver function test, grading of nausea, vomiting, mucositis and feile neutropenia in patient of hematological and solid malignancies.<b style="mso-bidi-font-weight:normal"><span style="color:black"> </span></b></span><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:&#10;&quot;Arial&quot;,&quot;sans-serif&quot;"><o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span style="font-size:13.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b style="mso-bidi-font-weight:&#10;normal"><span style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Materials and Methods: </span></b><span style="font-size:13.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-family:&quot;Times New Roman&quot;;mso-bidi-theme-font:minor-bidi;&#10;color:black">This is a <b style="mso-bidi-font-weight:normal">Observational case control study</b> in which 40 <b style="mso-bidi-font-weight:normal">Cases</b> received <b style="mso-bidi-font-weight:normal">chemotherapy plus standard antiemetics</b> <b style="mso-bidi-font-weight:normal">plus ginger</b> and 40 <b style="mso-bidi-font-weight:normal">Controls </b>received <b style="mso-bidi-font-weight:&#10;normal">chemotherapy plus standard antiemetics only.</b> <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Patients were randomized by computer generated random number table and ginger was started in dose of <b style="mso-bidi-font-weight:normal">1.5 gm/day in three divided doses</b> from first day of chemotherapy up to 4 days. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">All the cases were evaluated in follow-up visits at 1, 2 &amp; 4 week.</span><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-layout-grid-align:&#10;none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Results: <o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-layout-grid-align:&#10;none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Statistically significant effects were observed in improvement of chemotherapy induced Nausea in patients. No significant differences were found in hemoglobin, total leukocyte count, platelet count, blood urea, s. creatinine, total bilirubin, SGOT, SGPT, in grading of vomiting, oral mucositis and feile neutropenia.<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;tab-stops:62.0pt;&#10;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:&#10;normal"><span style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"><span style="mso-tab-count:1">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><o:p></o:p></span></b></p> <p style="margin-top:0in;margin-right:0in;margin-bottom:6.0pt;margin-left:0in;&#10;tab-stops:160.85pt;background:white"><b><u><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;&#10;mso-fareast-font-family:CapitoliumNews-Bold">Conclusions</span></u></b><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-fareast-font-family:CapitoliumNews-Bold">:</span></b> <span style="color:black">In this study authors conclude that ginger significantly reduces <span style="mso-spacerun:yes">&nbsp;</span>chemotherapy induced nausea.</span><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black"><o:p></o:p></span></p>