Volume : 7, Issue : 2, February - 2018

A STUDY OF EFFECTS OF PREMDICATION WITH ORAL CLONIDINE ON HAEMODYNAEMIC CHANGES IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES

Dr. Shivali Pandey, Dr Shailendra Dawar

Abstract :

Objectives To assess the efficacy of oral clonidine 2-2.5mcg/kg as a premedication and its effect  on haemodynamic changes associated with creation of pneumoperitoneum in laparoscopic surgery.Finally to evaluate and compare the side effects and complications in control and study group.<o:p></o:p> Methodology The patients were randomly allocated to two groups of 30 each study and control group.The study group received oral clonidine 2-2.5mcg with a sip of water 90 min prior to surgery.The control group received ora vit. c tablets  as placebo with a sip of water 90 min prior to surgery. Systematic arterial pressure including the systolic diastolic and mean arterial pressure heart rate SpO2 and EtCO2  were timely recorded .<o:p></o:p> Results The results of the study indicate that premedication with oral clonidine (2-2.5mcg) in laparoscopic surgeries effectively counteracts the  haemodnamic changes due to creation of pneumoperitoneum.The observations  were discussed in terms of pulse rate , blood pressure SpO2 ETCO2, post operative pain defined by VAS  sedation score and side effects and it wasseen that Clonidine causes clinically significant reduction in pulse rate and blood pressure intraoperatively. Clonidine treated patients were sedated and comfortable postoperatively .The incidence of side effects was minimum in clonidine treated patients.<o:p></o:p> Conclusion.Premedication with oral clonidine (2-2.5mcg/kg) proved better than placebo in counteracting the haemodynaemic changes in laparoscpic surgeries.Clonidine causes clinically significant reduction in pulse rate and blood pressure intraoperatively. Clonidine treated patients were sedated and comfortable postoperatively .The incidence of side effects was minimum in clonidine treated patients.<o:p></o:p>

Keywords :

SpO2 (Saturation ) and EtCO2(End tidal carbon dioxide) Laparoscopic cholecystectomy; Pneumoperitoneum Haemodynamic response; Clonidine premedication

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

Dr. Shivali Pandey, Dr Shailendra Dawar, A STUDY OF EFFECTS OF PREMDICATION WITH ORAL CLONIDINE ON HAEMODYNAEMIC CHANGES IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-2, FEBRUARY-2018