Volume : 7, Issue : 3, March - 2018

Estimated Humoral Immune Status against Bordetella pertussis Among Military Recruits in Sana'a, Yemen

Nagi Alhaj, Faheem Al Mughales, Abdul Baki A. Al Robasi

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;tab-stops:right 3.0in"><b style="mso-bidi-font-weight:&#10;normal"><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;">Back ground and Objective</span></b><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: Pertussis is a major cause of morbidity and mortality in infants and children worldwide in spite of the availability of a good protected vaccine. The incidence or prevalence rate among children or adults in Yemen are unknown. To determine the level of IgG antibodies of <i style="mso-bidi-font-style:normal">Bordetella<em><span style="mso-bidi-font-style:italic"> pertussis. </span></em></i><em><b style="mso-bidi-font-weight:normal"><span style="mso-bidi-font-style:italic">Methods</span></b></em></span><span lang="EN-MY">: B</span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">lood samples were collected </span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-language:AR-YE">from participated </span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">military recruits and commercially available Enzyme-linked Immunosorbent Assay was used.<em> </em><span style="background:white">C</span>ross-sectional study was conducted</span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-language:AR-YE"> on 188</span><span lang="EN-MY" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> military recruits, </span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-language:EN-MY">between March and October 2013</span><span lang="EN-MY" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">.<b style="mso-bidi-font-weight:&#10;normal">Results:</b> <em>The </em>prevalence of&nbsp;<em><i>B. pertussis</i></em>&nbsp;protective </span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-language:AR-YE">rate</span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-language:AR-YE">among different age groups of military recruits was 92.6%. The highest rate of antibodies 100% was among age group below 20 years followed with 96.3% for &gt;35 years and the lowest protective rate was 89.5%o for age group 25-29 years old. 92.9% protective rate for age group 30-34 years.</span><em><span lang="EN-MY" style="font-size:12.0pt;&#10;line-height:200%"> While the seronegative rate was </span></em><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-language:AR-YE">7.4%</span><em><span lang="EN-MY" style="font-size:12.0pt;&#10;line-height:200%"> among all age group. Meanwhile, the<i> </i></span></em><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">levels of <i>B. pertussis</i> IgG antibodies were 38.8% who had IgG antibodies level between 1.51-1.99 IU/ml<b style="mso-bidi-font-weight:normal">. Conclusions. </b><span style="background:white">The findings of this study concluded that the Yemeni military recruits <span style="color:black">were not enough immunized to pertussis and with confirmed of low awareness about vaccination and medical history related to pertussis infection particularly among this high-risk of Yemeni community,</span>&nbsp;therefore the <span style="color:black">routine a cellular booster vaccination</span> of adults is a key way to indirectly protect infants and community.<o:p></o:p></span></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;tab-stops:right 3.0in"><span lang="EN-MY" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;background:white"><o:p>&nbsp;</o:p></span></p>