Volume : 7, Issue : 4, April - 2018

Association Between Polycystic Ovary Syndrome And Idiopathic Intracranial Hypertension In Female Reproductive Age Group

Dr. Sarika Avasthi, Dr. Asima Das, Dr. Debabrat Biswal

Abstract :

<p class="abstext" style="text-align:justify;line-height:200%;background:white"><span style="font-size:14.0pt;line-height:200%;color:#333333">Introduction : Idiopathic intracranial hypertension (IIH) is characterised by elevated intracranial pressure and occurs predominantly in obese women in the reproductive age group. Signs and symptoms of polycystic ovary syndrome (PCOS) often coexist in IIH. Here we tried to establish the association of IIH with PCOS in our setup.<o:p></o:p></span></p> <p class="abstext" style="text-align:justify;line-height:200%;background:white"><span style="font-size:14.0pt;line-height:200%;color:#333333">Material and methods: </span><span style="font-size:14.0pt;line-height:200%">In this study we included all female patients of child-bearing age who are diagnosed as IIH by neurosurgical team between the year March 2010 to March 2016. All the suspected patients (according to NIH diagnostic criteria) with PCOS were listed.<span style="mso-spacerun:yes">&nbsp; </span>Women with suspected PCOS underwent testing for LH, FSH, testosterone, and 17-hydroxyprogesterone serum levels. These women were referred for ultrasonography to confirm polycystic ovaries and to serve as a base line for future follow up.<span style="mso-spacerun:yes">&nbsp; </span>The<span style="mso-spacerun:yes">&nbsp; </span>prevalence of PCOS in these women with IIH was compared with the reported prevalence of PCOS in the general population. <span style="color:#333333"><o:p></o:p></span></span></p> <p class="abstext" style="text-align:justify;line-height:200%;background:white"><span style="font-size:14.0pt;line-height:200%;color:#333333">Results:<span style="mso-spacerun:yes">&nbsp; </span></span><span style="font-size:14.0pt;&#10;line-height:200%">During this period a total of<span style="mso-spacerun:yes">&nbsp; </span>98<span style="mso-spacerun:yes">&nbsp; </span>patients were diagnosed as<span style="mso-spacerun:yes">&nbsp; </span>IIH, 79<span style="mso-spacerun:yes">&nbsp; </span>(80.61%) of them were women, which were included in our study . After proper history taking and clinical examination we found<span style="mso-spacerun:yes">&nbsp; </span>31 of the 79 women (39.24%) as being at risk for PCOS (all had either oligo-/anovulation or clinical signs of hyperandrogenism). After reviewing the hormonal status and physical examination results, thirteen (13/79; 16.45%) had definite PCOS. Ultrasonography<span style="mso-spacerun:yes">&nbsp; </span>proved the presence of polycystic ovaries in all these women. <span style="color:#333333"><o:p></o:p></span></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:#333333;background:white">Conclusion: The results of our study indicate a distinct association of IIH with PCOS.<span style="mso-spacerun:yes">&nbsp; </span>We found<span style="mso-spacerun:yes">&nbsp; </span>that regularly<span style="mso-spacerun:yes">&nbsp; </span>the features androgen excess and obesity are variably present in poly cystic ovary syndrome (PCOS) and idiopathic intracranial pressure (IIH).</span><span style="font-size:14.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p>