Volume : 7, Issue : 4, April - 2018

ROLE OF CO-INFECTION OF HPV AND HSV IN CERVICAL CANCER

Dr. Aarti Sharma, Dr. Ambika S. Dubey

Abstract :

<p class="MsoNormal" style="line-height:200%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction-</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-US">Carcinoma cervix (CaCx) is one of the most common malignancy affecting women.Cervical dysplasia is an excellent example of what preventive medicine can accomplish. Thus screening programs for the detection and diagnosis of premalignant and malignant lesions of the cervix have been effective. </span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Human Papilloma Virus (HPV) with their oncogenic strains is virtually primary cause for CaCx.<span style="background:&#10;white"> HSV-2 being spread primarily by sexual contact, also has role in CaCx. And if its coinfection, the rate is ??</span><o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-weight:bold">Methodology-A Cross Sectional Study done among 150 women, having the history suspicious of CaCx. These were subjected to cervical biopsy. The reports of which were followed through histopathology, immunohistochemistry and PCR and were clinically correlated.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-weight:bold">Observation &ndash;</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Co-infection of HPV and HSV was found significantly associated with chronic cervicitis ( p value =0.011) and squamous cell carcinoma (p value=0.004)<span style="mso-bidi-font-weight:bold"><o:p></o:p></span></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-weight:bold">Conclusion &ndash;</span><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">It `can be suggested by these findings that HSV is playing role in the pathogenesis and if the women is secondarily infected with HPV there are increase chances for cervical cancer and therefore the screening levels should go a step ahead in identifying the HSV and coinfection at an early stage.<o:p></o:p></span></p>