Volume : 7, Issue : 6, June - 2018

ANTI - INFLAMMATORY ACTIVITY OF SIDDHA PREPARATION KANDU PAARANGI CHOORANAM (Pygmaeopremna herbacea (Roxb.) Moldenke POWDER)

Priyadharshini, Jenefa Rose Priya. T

Abstract :

<p class="MsoNormal" style="margin-left:-14.2pt"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Objective</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:-14.2pt"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">To evaluate the anti-inflammatory activity of the aqueous extract of <i style="mso-bidi-font-style:normal">Chooranam</i> (root powder) of <i style="mso-bidi-font-style:normal">Kandupaarangi</i> (<i>Pygmaeopremna herbacea </i><span style="mso-bidi-font-style:italic">(Roxb.) Moldenke), a Siddha formulation.</span></span><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:-14.2pt"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Method</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:-14.2pt"><i><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Pygmaeopremna herbacea</span></i><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> of the family Verbenaceae is a small shrub with its knot roots, grown in many types of grassland and also in various parts of India. The plant roots have been used in the treatment of sinusitis, various respiratory ailments, pyrexia, chronic rheumatic disorders etc. The present study intended at the evaluation of anti-inflammatory activity of the aqueous extracts of the root powder by <i>in vivo</i> method estimated on the Carrageenan induced paw oedema.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:-14.2pt"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Result</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:0in;text-indent:0in"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">The method showed significant (p &lt; 0.01) anti-inflammatory property of the different concentration of extracts tested with 63.75% as the highest inhibition.</span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:0in;text-indent:0in"><b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Conclusion</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:0in"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;">The aqueous extract of <i style="mso-bidi-font-style:normal">KandupaarangiChooranam</i>(AEKC) at the concentration of 400 mg/kg showed potent activity, compared with the standard drug Diclofenac sodium.</span><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p>