Volume : 7, Issue : 7, July - 2018

LIFESTYLE INDUCED OXIDATIVE STRESS AMONG DYSLIPIDEMIC SUBJECTS AND ITS RISK FOR PREHYPERTENSION

Sharmila K, Muhammed Ashraf K, Gayathri Ajith, Dinesh Roy D

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:&#10;text1">Dyslipidemia is a high level of lipids (cholesterol, triglycerides, or both) carried by lipoproteins in the blood. Oxidative stress is underling cause for the development of dyslipidemia and cardiovascular disease.</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;background:white">Prehypertension has been recently described as an independent category of blood pressure. Mounting evidence suggests that blood pressure in the prehypertensive range is associated with an increased risk of developing hypertension and cardiovascular disease. Several reports have assigned a critical role for oxidative stress in these disease processes.&nbsp;</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1"> Lifestyle behaviors such as alcohol consumption, smoking and stress have been associated with change in lipid metabolism and thereby increase in oxidative stress levels. The aim of the present study was to evaluate lifestyle induced oxidative stress by measuring the levels of lipid peroxidation as malondialdehyde (MDA) along with lipid profile among dyslipidemic subjects and its risk for prehypertension. Present study consists of 46 study subjects and 17 control subjects. The levels of lipid profile were significantly altered in the study subjects. Levels of MDA were significantly increased in study subjects than control subjects. These results provide some evidence regarding the role of increased reactive oxygen species and decreased antioxidant activity in subjects. Lifestyle modification along with physical activity, improved diet and antioxidant therapy can reduce the risk of prehypertension.</span></b><b><span style="font-size:10.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:red"><o:p></o:p></span></b></p>