Volume : 7, Issue : 7, July - 2018

Liver enzymes and lipid profile: Markers for disease management in HIV/AIDS patients on ART and ART- naive.

Karanpreet Bhutani, Kmds Panag

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:&#10;200%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:&#10;14.0pt;mso-bidi-font-size:12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Introduction<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">AIDS is a fatal illness caused by HIV. Antiretroviral therapy can cause dyslipidemia and liver disease.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:&#10;200%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:&#10;14.0pt;mso-bidi-font-size:12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Aim: <o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">To evaluate liver enzymes and lipid profile in 200 HIV/AIDS patients and compare these in HIV /AIDS patients on ART and ART- naive.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:14.0pt;mso-bidi-font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Results:<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">The mean AST, ALT and ALP in the ART group were 58.93&plusmn;89.19, 66.08&plusmn;121.34 and 113.81&plusmn;51.63 respectively as compared to 34.64&plusmn; 24.69, 33.18 &plusmn; 23.40 and 120.22 &plusmn;125.41 respectively in the ART-naive group. The mean Cholesterol, TG, VLDL, LDL and HDL in the ART-group were 161.55 &plusmn;77.33, 209.92 &plusmn;93.29, 38.82 &plusmn;13.93, 63.97 &plusmn;28.54 and 48.52 &plusmn;16.31 respectively compared to 138.65 &plusmn; 41.87,178.02 &plusmn;81.32 ,34.17 &plusmn; 14.35, 58.50 &plusmn; 33.02 and 46.53 &plusmn; 16.25 respectively in the ART-naive group.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:14.0pt;mso-bidi-font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Conclusion:</span></b><span lang="EN-IN" style="font-size:14.0pt;mso-bidi-font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Arial&quot;,&quot;sans-serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Timely assessment of liver enzymes and lipid profile will help in better subsequent management of the HIV/AIDS patients.<o:p></o:p></span></p>