Volume : 7, Issue : 6, June - 2018

GENETIC VARIATIONS WITHIN TWO SUBTYPES OF SALIS

P. Mohan Rao, M. Ramesh, Geetha K. Konathala, G. Sudhakar

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-style:italic">Background and objectives:</span></b><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-style:italic"> The investigation of human blood genetic markers is a convenient tool to study genetic variation within and between human populations. The present investigation reports the variation in the distribution of some genetic markers in Salis, an endogamous sub-population from State of Andhra Pradesh, India.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-style:italic">Methods:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-style:italic"> 210 venous blood samples collected from health and unrelated individuals living in Vizianagaram and Visakhapatnam cities were used for typing eight genetic markers. </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The data obtained was tabulated, analyzed, assessed and formulated.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-style:italic">Results:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-style:italic"> </span><span style="font-family:&quot;Bookman Old Style&quot;,&quot;serif&quot;">Only 5 enzymes namely 6PGD, G6PD, ESD, ACP1 and GLO1 systems exibit polymorphism in the present study. </span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">However, in the 6PGD system, the AC rare heterozygote phenotype was observed 10% of cases. Furthermore, rare variant, TF*CD in the Transferrin system has been observed. The allele frequency of TF*CD was found to be 0.01.<span style="mso-tab-count:1"> </span></span><span style="font-family:&quot;Bookman Old Style&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-style:italic">Conclusions:</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-bidi-font-style:italic"> The results of these biochemical genetic markers were found to be in accordance with other populations of Andhra Pradesh, South India.<o:p></o:p></span></p>