Volume : 7, Issue : 7, July - 2018

Bacteriological Profile and Antibiogram of Lower Respiratory tract infections in a tertiary care hospital.

Dr. S. K. Sathiya Priya, Dr. R. K. Geetha, Mrs. Ramya Kumaran

Abstract :

<p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aims:</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> The<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>present<span style="mso-spacerun:yes">&nbsp; </span>study<span style="mso-spacerun:yes">&nbsp; </span>was<span style="mso-spacerun:yes">&nbsp; </span>conducted<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>determine<span style="mso-spacerun:yes">&nbsp; </span>the<span style="mso-spacerun:yes">&nbsp; </span>bacterial<span style="mso-spacerun:yes">&nbsp; </span>aetiology<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>antimicrobial<span style="mso-spacerun:yes">&nbsp; </span>susceptibility<span style="mso-spacerun:yes">&nbsp; </span>pattern<span style="mso-spacerun:yes">&nbsp; </span>of<span style="mso-spacerun:yes">&nbsp; </span>lower<span style="mso-spacerun:yes">&nbsp; </span>respiratory<span style="mso-spacerun:yes">&nbsp; </span>tract<span style="mso-spacerun:yes">&nbsp; </span>infections<span style="mso-spacerun:yes">&nbsp; </span>so<span style="mso-spacerun:yes">&nbsp; </span>as<span style="mso-spacerun:yes">&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>update<span style="mso-spacerun:yes">&nbsp; </span>the<span style="mso-spacerun:yes">&nbsp; </span>clinicians<span style="mso-spacerun:yes">&nbsp; </span>in<span style="mso-spacerun:yes">&nbsp; </span>various<span style="mso-spacerun:yes">&nbsp; </span>antimicrobial<span style="mso-spacerun:yes">&nbsp; </span>alternatives<span style="mso-spacerun:yes">&nbsp; </span>available<span style="mso-spacerun:yes">&nbsp; </span>in<span style="mso-spacerun:yes">&nbsp; </span>the<span style="mso-spacerun:yes">&nbsp; </span>treatment. <b style="mso-bidi-font-weight:&#10;normal">Methods:<span style="mso-spacerun:yes">&nbsp; </span></b>177<span style="mso-spacerun:yes">&nbsp; </span>sputum<span style="mso-spacerun:yes">&nbsp; </span>samples<span style="mso-spacerun:yes">&nbsp; </span>from<span style="mso-spacerun:yes">&nbsp; </span>patients<span style="mso-spacerun:yes">&nbsp; </span>with<span style="mso-spacerun:yes">&nbsp; </span>lower<span style="mso-spacerun:yes">&nbsp; </span>respiratory<span style="mso-spacerun:yes">&nbsp; </span>tract<span style="mso-spacerun:yes">&nbsp; </span>infections<span style="mso-spacerun:yes">&nbsp; </span>were<span style="mso-spacerun:yes">&nbsp; </span>collected<span style="mso-spacerun:yes">&nbsp; </span>in<span style="mso-spacerun:yes">&nbsp; </span>time<span style="mso-spacerun:yes">&nbsp; </span>span<span style="mso-spacerun:yes">&nbsp; </span>of<span style="mso-spacerun:yes">&nbsp; </span>3months. Bacterial<span style="mso-spacerun:yes">&nbsp; </span>pathogens<span style="mso-spacerun:yes">&nbsp; </span>were<span style="mso-spacerun:yes">&nbsp; </span>isolated<span style="mso-spacerun:yes">&nbsp; </span>from<span style="mso-spacerun:yes">&nbsp; </span>sputum<span style="mso-spacerun:yes">&nbsp; </span>specimens<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>subjected<span style="mso-spacerun:yes">&nbsp; </span>to antibiotic<span style="mso-spacerun:yes">&nbsp; </span>susceptibility<span style="mso-spacerun:yes">&nbsp; </span>testing<span style="mso-spacerun:yes">&nbsp; </span>using<span style="mso-spacerun:yes">&nbsp; </span>standard<span style="mso-spacerun:yes">&nbsp; </span>bacteriologic<span style="mso-spacerun:yes">&nbsp; </span>techniques. <b style="mso-bidi-font-weight:normal">Results: </b>Out<span style="mso-spacerun:yes">&nbsp; </span>of<span style="mso-spacerun:yes">&nbsp; </span>177 cases<span style="mso-spacerun:yes">&nbsp; </span>only<span style="mso-spacerun:yes">&nbsp; </span>46 (26%)<span style="mso-spacerun:yes">&nbsp; </span>had<span style="mso-spacerun:yes">&nbsp; </span>an<span style="mso-spacerun:yes">&nbsp; </span>established<span style="mso-spacerun:yes">&nbsp; </span>aetiology. Males<span style="mso-spacerun:yes">&nbsp; </span>102 (57.6%)<span style="mso-spacerun:yes">&nbsp; </span>were<span style="mso-spacerun:yes">&nbsp; </span>more<span style="mso-spacerun:yes">&nbsp; </span>commonly<span style="mso-spacerun:yes">&nbsp; </span>affected<span style="mso-spacerun:yes">&nbsp; </span>than<span style="mso-spacerun:yes">&nbsp; </span>Females 75(42.4%) .The<span style="mso-spacerun:yes">&nbsp; </span>most<span style="mso-spacerun:yes">&nbsp; </span>prevalent<span style="mso-spacerun:yes">&nbsp; </span>bacterial<span style="mso-spacerun:yes">&nbsp; </span>pathogen<span style="mso-spacerun:yes">&nbsp; </span>was<span style="mso-spacerun:yes">&nbsp; </span>Klebsiellapneumoniae<span style="mso-spacerun:yes">&nbsp; </span>37(80.4%)<span style="mso-spacerun:yes">&nbsp; </span>followed<span style="mso-spacerun:yes">&nbsp; </span>by<span style="mso-spacerun:yes">&nbsp; </span>Pseudomonas<span style="mso-spacerun:yes">&nbsp; </span>aeuroginosa<span style="mso-spacerun:yes">&nbsp; </span>6( 13%)<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>Acinetobacter<span style="mso-spacerun:yes">&nbsp; </span>spp. 3(6.6%).Klebsiellapneumoniae<span style="mso-spacerun:yes">&nbsp; </span>was<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>most<span style="mso-spacerun:yes">&nbsp; </span>sensitive<span style="mso-spacerun:yes">&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>Amikacin, Ciprofloxacin<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>Gentamycin<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>resistant<span style="mso-spacerun:yes">&nbsp; </span>to Doxycycline. Pseudomonas<span style="mso-spacerun:yes">&nbsp; </span>aeuroginosa<span style="mso-spacerun:yes">&nbsp; </span>was<span style="mso-spacerun:yes">&nbsp; </span>sensitive<span style="mso-spacerun:yes">&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>Meropenem, Toamycin<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>Ceftazidime. Acinetobacter<span style="mso-spacerun:yes">&nbsp; </span>spp.<span style="mso-spacerun:yes">&nbsp; </span>showed<span style="mso-spacerun:yes">&nbsp; </span>maximum<span style="mso-spacerun:yes">&nbsp; </span>sensitivity<span style="mso-spacerun:yes">&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>Ciprofloxacin, Ofloxacin<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>Ceftriaxone<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>resistant<span style="mso-spacerun:yes">&nbsp; </span>to<span style="mso-spacerun:yes">&nbsp; </span>Cotrimoxazole<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>Doxycycline.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">:<span style="mso-spacerun:yes">&nbsp; </span>For<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>the<span style="mso-spacerun:yes">&nbsp; </span>effective management<span style="mso-spacerun:yes">&nbsp; </span>of<span style="mso-spacerun:yes">&nbsp; </span>lower<span style="mso-spacerun:yes">&nbsp; </span>respiratory<span style="mso-spacerun:yes">&nbsp; </span>tract<span style="mso-spacerun:yes">&nbsp; </span>infections<span style="mso-spacerun:yes">&nbsp; </span>bacteriological<span style="mso-spacerun:yes">&nbsp; </span>diagnosis<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>antimicrobial<span style="mso-spacerun:yes">&nbsp; </span>susceptibility<span style="mso-spacerun:yes">&nbsp; </span>pattern<span style="mso-spacerun:yes">&nbsp; </span>is<span style="mso-spacerun:yes">&nbsp; </span>indispensable.<o:p></o:p></span></p>