Volume : 7, Issue : 7, July - 2018

Citrobacter Species: An Emerging Nosocomial Pathogen and its Antibiotic resistance pattern at a tertiary care centre

Dr Mayuri Bhise, Dr Ruchita Gawande, Dr Anu Sharma, Dr Kishor Ingole

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">BACKGROUND &amp; OBJECTIVES: </span></b><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Citrobacter species are a distinct group of aerobic gram negative bacilli of Family Enterobacteriaceae. Citrobacter species have been reported to cause wide range ofinfections with simple Urinary tract Infections to Septicaemia.<span style="mso-spacerun:yes">&nbsp; </span>Although Citrobacter species once considered as less frequent nosocomial pathogen, at present they are posing a major health concern to the microbiologist &amp; clinician because of their multiple drug resistance.<b style="mso-bidi-font-weight:normal">AIMS AND OBJECTIVES:-a)</b>Tocharacterize the infections caused by Citrobacter species. b) To study the occurrence of risk factors for infection with Citrobacter species c)To assess the antibiotic susceptibility pattern of Citrobacter species <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">MATERIALS AND METHODS: </span></b><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">During the study period of one year from May 2017 to April 2018, 800 clinical specimens were collected and processed from patients with different risk factors.Citrobacter species isolated <span style="mso-spacerun:yes">&nbsp;&nbsp;</span>and were speciated using biochemical reactions. Antibiogram of Citrobacter species was performed and interpreted as per CLSI guidelines<o:p></o:p></span></p> <p class="Default" style="text-align:justify"><b style="mso-bidi-font-weight:&#10;normal"><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">RESULTS: </span></b><span lang="EN-IN" style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Of the 800 samples 250 Citrobacter species were isolated .There was a highly significant difference in the resistance of the Citrobacter isolates to all the antimicrobials including beta lactams, quinolones and aminoglycosides. ESBL production was seen in 64% of the hospital <b style="mso-bidi-font-weight:normal">CONCLUSION: </b>The present study highlighted the impact of<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Nosocomial infections caused by Citrobacter species &amp; its multiple drug resistance nature towards commonly used antibiotics..</span><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"><o:p></o:p></span></p>