Volume : 7, Issue : 8, August - 2018

Association between inflammatory marker and Cognitive Impairment in Diagnosed Type 2 Diabetes Mellitus: A Case Control Study.

Dr. Mir Abdul Munif, Dr. Malik Faizan Ahmad

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction: </span></b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Type 2 diabetes mellitus (T2DM) is a common metabolic disease, especially in older people, with global prevalence estimates ranging from 2.8% in 2000 to a projected 4.4% in 2030 (Wild S et al.2004).<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p>&nbsp;</o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Objectives</span></b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-bidi-font-weight:&#10;bold">: </span><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-language:EN-GB;mso-bidi-font-weight:bold">The present study was undertaken to assess association between inflammatory marker&amp;</span><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Cognitive impairementin people with type 2 diabetes mellitus.</span><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-language:&#10;EN-GB;mso-bidi-font-weight:bold"><o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:normal;background:&#10;white"><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:normal;background:&#10;white"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Methods: </span></b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The present study was conducted in Rajeev Gandhi Centre for Diabetes and Endocrinology and Department of Physiology on patients of Type 2 Diabetes Mellitus attending Diabetes clinic in Jawaharlal Nehru Medical college hospital, Aligarh Muslim University during year 2012-2013 after approval from the ethical committee of J. N. Medical College. Design of the study was case control.A detailed history and physical examination was carried out for every subject who entered the study as per pre-designed proforma.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Results: </span></b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">For cognitive impairment, Type 2 DM subjects showed significantly decrease total MMSE score with decrease in orientation, registration,attention and calculation, recall and language in comparison to controls.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion: </span></b><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The association between Type 2 DM and cognitive changes is becoming increasingly clear, rendering it necessary for physicians in charge of diabetic patients to have the means to assess cognitive performance as cognitive impairment among the older adults with Type 2 DM may worsen the health outcomes through negative impact on compliance with medical self care recommendations.<o:p></o:p></span></p>