Volume : 7, Issue : 8, August - 2018

Assessment of therapeutic efficacy and safety of delphinium denudatum wall (jadwar) and local application of Iris florentina (roghan sosan) in painful diabetic neuropathy: A randomised single blind standard controlled study.

Dr Zaffar Hussain

Abstract :

<p class="Default"><span lang="EN-IN">The current study was conducted to assess the efficacy and safety of <i>Delphinium denudatum</i>(<i>Jadwar</i>)androghansosan in patients with painful diabetic neuropathy. A randomised single-blind standard controlled trial was carried out on 30 diagnosed patients of painful diabetic neuropathy at National Institute of Unani Medicine Bangalore-India. After obtaining ethical clearance, 30 eligible patients were randomly allocated into test and control groups, comprising 15 patients in each group. Patients of test group were given Delphinium denudatum wall<i> (Jadwar</i>) 500mg in tablet form twice daily and local application of;<span style="mso-bidi-font-weight:&#10;bold;mso-bidi-font-style:italic">Iris florentina</span><span style="mso-spacerun:yes">&nbsp; </span>(<i>roghansosan</i>) on both feet twice daily. The patients of control group were given Strychnosnuxvomica<i> (Azaraqi</i>) 500 mg in tablet form twice daily for a period of 45 days. The subjective parameter- Visual analogue scale (VAS) was statistically analysed by applying Student&rsquo;s &lsquo;t&rsquo; test, two tailed dependent for intragroup comparison, two tailed independent for intergroup comparison and Levene&rsquo;s test for the homogeneity of variance. VAS showed strongly significant difference (p&lt;0.001) in intragroup comparison in both groups. The study revealed that test drugs appeared to be efficacious in the management of painful<span style="mso-spacerun:yes">&nbsp; </span>diabetic neuropathy and exhibited significant effects in improvement of neuronal function. No adverse effects or toxicity has been reported during or after the trial. </span></p>